Imene Ben Jdidia1, Kaouther Zribi2, Meriam Boubaker3, Amira Brahem4, Mouna Sayadi5, Marwa Tlijani5, Zahra Saidani6, Amani Cherif7. 1. , Pharm. D., est une Pharmacienne spécialiste des hôpitaux et assistante hospitalo-universitaire en pharmacie hospitalière, Hôpital Fattouma Bourguiba de Monastir, Monastir, Tunisie. 2. , Pharm. D., Ph. D., est une Pharmacienne spécialiste des hôpitaux et assistante hospitalo-universitaire en pharmacie hospitalière, Centre de maternité et de néonatologie de Monastir, Monastir, Tunisie. 3. , Pharm. D., est une Pharmacienne et responsable de recherche et développement, Génome Humain et Maladies Multifactorielles (LR12ES07), Faculté de pharmacie, Université de Monastir, Monastir, Tunisie. 4. , Pharm. D., est Pharmacienne et responsable de recherche et développement, Génome Humain et Maladies Multifactorielles (LR12ES07), Faculté de pharmacie, Université de Monastir, Monastir, Tunisie. 5. , Pharm. D., est une Pharmacienne spécialiste des hôpitaux et assistante hospitalo-universitaire en pharmacie hospitalière, Centre de maternité et de néonatologie de Monastir, Monastir, Tunisie. 6. , MD, Médecin spécialiste en gynécologie et obstétrique, est professeur en médecine, Centre de maternité et de néonatologie de Monastir, Monastir, Tunisie. 7. , Pharm. D., Ph. D., est une Pharmacienne spécialiste des hôpitaux et professeur agrégé en pharmacie hospitalière, Centre de maternité et de néonatologie de Monastir, Génome Humain et Maladies Multifactorielles (LR12ES07), Faculté de pharmacie, Université de Monastir, Monastir, Tunisie.
Abstract
BACKGROUND: Biological assessment is an integral part of the diagnostic process that guides therapeutic management decisions. However, these analyses remain subject to interference from endogenous or exogenous factors, which may alter the results. OBJECTIVE: To provide an up-to-date and comprehensive overview of the most commonly documented types of interference attributable to medications, to ensure reliable interpretation of test results and better management of patients. DATA SOURCES: This comprehensive systematic review of the literature was carried out in 2018. The bibliographic search was carried out in various online databases, specifically PubMed, ScienceDirect and Google Scholar. STUDY SELECTION: Only publications in French or English concerning medicinal products for human use were retained. The investigators' examination of drug-related interference with laboratory tests was limited to blood assays (serum or plasma). DATA EXTRACTION: An Excel spreadsheet was used to analyze the results. A total of 82 articles were selected. The interferences studied affected 47 biological parameters corresponding to various types of assessment: hormonal, hepatic, and renal. DATA SYNTHESIS: The mechanisms reported in the literature identified were analytical (56.9%), physiological (17.82%), and pharmacological (20.11%). The remainder of the mechanisms (5.17%) were not defined. CONCLUSIONS: Clinicians should be vigilant in validating and interpreting laboratory test results for patients receiving these types of drugs. Dialogue between clinicians and biological scientists is the best way to avoid unnecessary additional testing, which is often cumbersome and costly. 2021 Canadian Society of Hospital Pharmacists. All content in the Canadian Journal of Hospital Pharmacy is copyrighted by the Canadian Society of Hospital Pharmacy. In submitting their manuscripts, the authors transfer, assign, and otherwise convey all copyright ownership to CSHP.
BACKGROUND: Biological assessment is an integral part of the diagnostic process that guides therapeutic management decisions. However, these analyses remain subject to interference from endogenous or exogenous factors, which may alter the results. OBJECTIVE: To provide an up-to-date and comprehensive overview of the most commonly documented types of interference attributable to medications, to ensure reliable interpretation of test results and better management of patients. DATA SOURCES: This comprehensive systematic review of the literature was carried out in 2018. The bibliographic search was carried out in various online databases, specifically PubMed, ScienceDirect and Google Scholar. STUDY SELECTION: Only publications in French or English concerning medicinal products for human use were retained. The investigators' examination of drug-related interference with laboratory tests was limited to blood assays (serum or plasma). DATA EXTRACTION: An Excel spreadsheet was used to analyze the results. A total of 82 articles were selected. The interferences studied affected 47 biological parameters corresponding to various types of assessment: hormonal, hepatic, and renal. DATA SYNTHESIS: The mechanisms reported in the literature identified were analytical (56.9%), physiological (17.82%), and pharmacological (20.11%). The remainder of the mechanisms (5.17%) were not defined. CONCLUSIONS: Clinicians should be vigilant in validating and interpreting laboratory test results for patients receiving these types of drugs. Dialogue between clinicians and biological scientists is the best way to avoid unnecessary additional testing, which is often cumbersome and costly. 2021 Canadian Society of Hospital Pharmacists. All content in the Canadian Journal of Hospital Pharmacy is copyrighted by the Canadian Society of Hospital Pharmacy. In submitting their manuscripts, the authors transfer, assign, and otherwise convey all copyright ownership to CSHP.
Entities:
Keywords:
biological assessments; drug-related laboratory test interference (DLTI); drugs
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