| Literature DB >> 34602305 |
Abstract
RNA splicing, the process by which precursor mRNA (pre-mRNA) is processed to mature mRNA, is catalyzed by the spliceosome. Recently, Chatrikhi et al. identified pharmacologic means to perturb splicing by enhancing the spliceosome's binding to pre-mRNA. This represents a novel chemical target and mechanism for therapeutic modulation of splicing.Entities:
Keywords: RBM39; RNA; SF3B1; U2AF1; myelodysplastic syndromes; splicing
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Year: 2021 PMID： 34602305 DOI： 10.1016/j.tips.2021.09.006
Source DB: PubMed Journal: Trends Pharmacol Sci ISSN： 0165-6147 Impact factor: 14.819