Literature DB >> 34600851

Radiation-Induced Changes in Ventricular Myocardium After Stereotactic Body Radiotherapy for Recurrent Ventricular Tachycardia.

Josef Kautzner1, Kristina Jedlickova2, Marek Sramko3, Petr Peichl3, Jakub Cvek4, Lukas Knybel Ing4, Radek Neuwirth5, Otakar Jiravsky5, Ludek Voska2, Tomas Kucera6.   

Abstract

Stereotactic body radiotherapy (SBRT) has been suggested as a promising therapeutic alternative in cases of failed catheter ablation for recurrent ventricular tachycardias (VTs) in patients with structural heart disease. This case series is the first postmortem immunohistochemical analysis of morphologic changes in the myocardium early and late after SBRT. The present findings are in line with experimental observations on apoptosis followed by fibrosis. This may explain why the effect of SBRT on VT is not predominantly immediate. Together with observation of early recurrences after SBRT for VT, these data suggest that this strategy may have rather delayed antiarrhythmic effects.
Copyright © 2021 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

Entities:  

Keywords:  catheter ablation; histology; immunohistochemistry; radiotherapy; ventricular tachycardia

Mesh：

Year:  2021        PMID： 34600851     DOI： 10.1016/j.jacep.2021.07.012

Source DB:  PubMed          Journal:  JACC Clin Electrophysiol        ISSN： 2405-500X


  4 in total

1.  Case Report: Repeated Stereotactic Radiotherapy of Recurrent Ventricular Tachycardia: Reasons, Feasibility, and Safety.

Authors:  Jana Haskova; Petr Peichl; Marek Šramko; Jakub Cvek; Lukáš Knybel; Otakar Jiravský; Radek Neuwirth; Josef Kautzner
Journal:  Front Cardiovasc Med       Date:  2022-03-28

2.  Histopathological Examination of an Explanted Heart in a Long-Term Responder to Cardiac Stereotactic Body Radiotherapy (STereotactic Arrhythmia Radioablation).

Authors:  Marcin Miszczyk; Mateusz Sajdok; Jerzy Nożyński; Magdalena Cybulska; Jacek Bednarek; Tomasz Jadczyk; Tomasz Latusek; Radoslaw Kurzelowski; Łukasz Dolla; Wojciech Wojakowski; Agnieszka Dyla; Michał Zembala; Anna Drzewiecka; Konrad Kaminiów; Anna Kozub; Ewa Chmielik; Aleksandra Grza Dziel; Adam Bekman; Krzysztof Stanisław Gołba; Sławomir Blamek
Journal:  Front Cardiovasc Med       Date:  2022-07-07

3.  Stereotactic body radioablation therapy as an immediate and early term antiarrhythmic palliative therapeutic choice in patients with refractory ventricular tachycardia.

Authors:  Dursun Aras; Elif Hande Özcan Çetin; Huseyin Furkan Ozturk; Elif Ozdemir; Meryem Kara; Firdevs Aysenur Ekizler; Ozcan Ozeke; Firat Ozcan; Ahmet Korkmaz; Umit Kervan; Nesrin Turhan; Nazim Coskun; Yilmaz Tezcan; Henry Huang; Tolga Aksu; Serkan Topaloglu
Journal:  J Interv Card Electrophysiol       Date:  2022-08-30       Impact factor: 1.759

Review 4.  The effect of ionizing radiation through cardiac stereotactic body radiation therapy on myocardial tissue for refractory ventricular arrhythmias: A review.

Authors:  John Whitaker; Paul C Zei; Shahreen Ahmad; Steven Niederer; Mark O'Neill; Christopher A Rinaldi
Journal:  Front Cardiovasc Med       Date:  2022-09-15
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.