Shmuel Zangen1,2, Simon Shenhav3,2, Yaniv S Ovadia4,5, Shani R Rosen6, Dov Gefel6, Shlomo Almashanu7, Carlos Benbassat8,9, Shlomo Fytlovich10, Dorit Aharoni10, Eyal Y Anteby3,2. 1. Department of Neonatology, Barzilai University Medical Center Ashkelon, Ashkelon, Israel. 2. Faculty of Health Sciences, Ben-Gurion University of Negev, Beer-Sheva, Israel. 3. Obstetrics and Gynecology Department, Barzilai University Medical Center Ashkelon, Ashkeon, Israel. 4. Obstetrics and Gynecology Department, Barzilai University Medical Center Ashkelon, Ashkeon, Israel. yaniv.ovadia@mail.huji.ac.il. 5. Foreign studies department; Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rhovot, Israel. yaniv.ovadia@mail.huji.ac.il. 6. School of Nutritional Science, Institute of Biochemistry, Food Science and Nutrition; Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel. 7. National Newborn Screening Program, Ministry of Health, Tel-Hashomer, Israel. 8. Endocrine Institute, Shamir Medical Center, Zerifin, Israel. 9. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. 10. Laboratory of Clinical Biochemistry, Barzilai University Medical Center Ashkelon, Ashkelon, Israel.
Abstract
OBJECTIVES: Childhood obesity and iodine deficiency are global public health concerns. Whether maternal iodine status mediates overweight in infancy has yet to be explored. We aimed to assess the relationship between maternal iodine status and infant birth weight, including small and large for gestational age (SGA and LGA, respectively). METHODS: A prospective study was carried out among 134 mother-infant pairs from Israel. Maternal iodine intake and status were estimated via questionnaire and serum thyroglobulin (Tg), respectively. Estimated iodine intake below the Recommended Daily Allowance for iodine sufficiency in pregnancy (220 μg/d) considered Inadequate. Maternal and neonatal thyroid function and anthropometric measurements, as well as maternal thyroid antibodies were also tested. RESULTS: After screening, 118 participants met the inclusion criteria (distributed trimesters I, II and III: n = 3, n = 21, and n = 94, respectively). There was a negative association of iodine intake with Tg values among the study population. Maternal median Tg value was higher than the sufficiency cutoff (16.5 vs 13 µg/L), indicating insufficient iodine status. No SGA cases were found. Inadequate iodine intake was associated with maternal isolated hypothyroxinemia (OR = 3.4; 95% CI 1.2, 9.9) and higher birthweight (including macrosomia and LGA) rates. A suggestive association of elevated Tg with a greater risk of LGA was observed. Offsprings' birth weight percentiles were associated with Tg values in pregnant women with suggestive sufficient iodine status (n = 62, R2 = 0.11, p < 0.05). CONCLUSIONS: Iodine status during pregnancy can be associated with newborn anthropometric index. Maternal inadequate iodine intake may alter fetal growth and might increase the risk of LGA among newborns. These initial findings support the need to further study the impact of iodine deficiency on newborns overweight in Israel and elsewhere.
OBJECTIVES: Childhood obesity and iodine deficiency are global public health concerns. Whether maternal iodine status mediates overweight in infancy has yet to be explored. We aimed to assess the relationship between maternal iodine status and infant birth weight, including small and large for gestational age (SGA and LGA, respectively). METHODS: A prospective study was carried out among 134 mother-infant pairs from Israel. Maternal iodine intake and status were estimated via questionnaire and serum thyroglobulin (Tg), respectively. Estimated iodine intake below the Recommended Daily Allowance for iodine sufficiency in pregnancy (220 μg/d) considered Inadequate. Maternal and neonatal thyroid function and anthropometric measurements, as well as maternal thyroid antibodies were also tested. RESULTS: After screening, 118 participants met the inclusion criteria (distributed trimesters I, II and III: n = 3, n = 21, and n = 94, respectively). There was a negative association of iodine intake with Tg values among the study population. Maternal median Tg value was higher than the sufficiency cutoff (16.5 vs 13 µg/L), indicating insufficient iodine status. No SGA cases were found. Inadequate iodine intake was associated with maternal isolated hypothyroxinemia (OR = 3.4; 95% CI 1.2, 9.9) and higher birthweight (including macrosomia and LGA) rates. A suggestive association of elevated Tg with a greater risk of LGA was observed. Offsprings' birth weight percentiles were associated with Tg values in pregnant women with suggestive sufficient iodine status (n = 62, R2 = 0.11, p < 0.05). CONCLUSIONS: Iodine status during pregnancy can be associated with newborn anthropometric index. Maternal inadequate iodine intake may alter fetal growth and might increase the risk of LGA among newborns. These initial findings support the need to further study the impact of iodine deficiency on newborns overweight in Israel and elsewhere.
Authors: Michael B Zimmermann; Małgorzata Gizak; Karen Abbott; Maria Andersson; John H Lazarus Journal: Lancet Diabetes Endocrinol Date: 2015-08-09 Impact factor: 32.069
Authors: Yaniv S Ovadia; Jonathan E Arbelle; Dov Gefel; Hadassah Brik; Tamar Wolf; Varda Nadler; Sandra Hunziker; Michael B Zimmermann; Aron M Troen Journal: Thyroid Date: 2017-08 Impact factor: 6.568
Authors: Jonathan D Winter; Yhenneko Taylor; Lauren Mowrer; Katherine M Winter; Michael F Dulin Journal: Obes Res Clin Pract Date: 2016-04-08 Impact factor: 2.288
Authors: Marianne Hope Abel; Ida Henriette Caspersen; Verena Sengpiel; Bo Jacobsson; Helle Margrete Meltzer; Per Magnus; Jan Alexander; Anne Lise Brantsæter Journal: BMC Med Date: 2020-08-11 Impact factor: 8.775