Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Coenzyme Q10 a mitochondrial restorer for various brain disorders.

Literature DB >> 34596729

Coenzyme Q10 a mitochondrial restorer for various brain disorders.

Nilima Pradhan^1,2, Charan Singh^3,2, Arti Singh^4,5.

Abstract

Coenzyme Q10 (ubiquinone or CoQ10) is a lipid molecule that acts as an electron mobile carrier of the electron transport chain and also contains antioxidant properties. Supplementation of CoQ10 has been very useful to treat mitochondrial diseases. CoQ10 along with its synthetic analogue, idebenone, is used largely to treat various neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, Huntington's disease, Amyotrophic lateral sclerosis, and Friedreich's ataxia and additional brain disease condition like autism, multiple sclerosis, epilepsy, depression, and bipolar disorder, which are related to mitochondrial impairment. In this article, we have reviewed numerous physiological functions of CoQ10 and the rationale for its use in clinical practice in different brain disorders.

Entities: Chemical

Keywords: Alzheimer’s disease; Amyotrophic lateral sclerosis; Autism; Bipolar disorder; Coenzyme Q10; Depression; Epilepsy; Friedreich’s ataxia; Huntington’s disease; Multiple sclerosis; Parkinson’s disease

Mesh：

Substances：

Year: 2021 PMID： 34596729 DOI： 10.1007/s00210-021-02161-8

Source DB: PubMed Journal: Naunyn Schmiedebergs Arch Pharmacol ISSN： 0028-1298 Impact factor: 3.195

132 in total

Review 1. Mitochondrial protein quality control during biogenesis and aging.

Authors: Brooke M Baker; Cole M Haynes
Journal: Trends Biochem Sci Date: 2011-02-25 Impact factor: 13.807

2. Targeting Oxidative Stress, Cytokines and Serotonin Interactions Via Indoleamine 2, 3 Dioxygenase by Coenzyme Q10: Role in Suppressing Depressive Like Behavior in Rats.

Authors: Sally A Abuelezz; Nevien Hendawy; Yosra Magdy
Journal: J Neuroimmune Pharmacol Date: 2016-10-11 Impact factor: 4.147

3. Regulation of mitochondrial iron accumulation by Yfh1p, a putative homolog of frataxin.

Authors: M Babcock; D de Silva; R Oaks; S Davis-Kaplan; S Jiralerspong; L Montermini; M Pandolfo; J Kaplan
Journal: Science Date: 1997-06-13 Impact factor: 47.728

4. Mitochondrial complex I activity and oxidative damage to mitochondrial proteins in the prefrontal cortex of patients with bipolar disorder.

Authors: Ana C Andreazza; Li Shao; Jun-Feng Wang; L Trevor Young
Journal: Arch Gen Psychiatry Date: 2010-04

5. Coenzyme Q10 displays antidepressant-like activity with reduction of hippocampal oxidative/nitrosative DNA damage in chronically stressed rats.

Authors: Sawsan Aboul-Fotouh
Journal: Pharmacol Biochem Behav Date: 2013-01-11 Impact factor: 3.533

6. Coenzyme q10 ameliorates neurodegeneration, mossy fiber sprouting, and oxidative stress in intrahippocampal kainate model of temporal lobe epilepsy in rat.

Authors: Tourandokht Baluchnejadmojarad; Mehrdad Roghani
Journal: J Mol Neurosci Date: 2012-09-25 Impact factor: 3.444

Coenzyme Q10 a mitochondrial restorer for various brain disorders.

Review 1. Mitochondrial protein quality control during biogenesis and aging.

2. Targeting Oxidative Stress, Cytokines and Serotonin Interactions Via Indoleamine 2, 3 Dioxygenase by Coenzyme Q10: Role in Suppressing Depressive Like Behavior in Rats.

3. Regulation of mitochondrial iron accumulation by Yfh1p, a putative homolog of frataxin.

4. Mitochondrial complex I activity and oxidative damage to mitochondrial proteins in the prefrontal cortex of patients with bipolar disorder.

5. Coenzyme Q10 displays antidepressant-like activity with reduction of hippocampal oxidative/nitrosative DNA damage in chronically stressed rats.

6. Coenzyme q10 ameliorates neurodegeneration, mossy fiber sprouting, and oxidative stress in intrahippocampal kainate model of temporal lobe epilepsy in rat.

7. Coenzyme Q₁₀ Alleviated Behavioral Dysfunction and Bioenergetic Function in an Animal Model of Depression.

8. Immune mechanisms linked to depression via oxidative stress and neuroprogression.

Review 9. The association between Diabetes mellitus and Depression.

Review 10. Mitochondria and Mood: Mitochondrial Dysfunction as a Key Player in the Manifestation of Depression.

Review 1. Molecular mechanisms underlying the renal protective effects of coenzyme Q10 in acute kidney injury.

Review 2. Amyotrophic Lateral Sclerosis: A Diet Review.