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Literature DB >> 3459171

Antibody to a molecular marker of cell position inhibits synapse formation in retina.

Abstract

A topographic gradient of TOP molecules in retina can be used to identify neuron position. Antibody to TOP from hybridoma cells that were injected into in vivo embryo eyes diffused into the retina and bound in a topographic gradient of [antibody.TOP] ([Ab.TOP]) complexes. Synapse formation in retina was inhibited in the presence of anti-TOP antibody. This suggests that TOP is involved in synapse formation and that recognition of position by neurons is necessary for normal synapse formation.

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Year: 1986 PMID： 3459171 PMCID： PMC323698 DOI： 10.1073/pnas.83.12.4194

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

23 in total

1. DESTRUCTION OF THE SYMPATHETIC GANGLIA IN MAMMALS BY AN ANTISERUM TO A NERVE-GROWTH PROTEIN.

Authors: R Levi-Montalcini; B Booker
Journal: Proc Natl Acad Sci U S A Date: 1960-03 Impact factor: 11.205

2. Adhesion among neural cells of the chick embryo. II. Purification and characterization of a cell adhesion molecule from neural retina.

Authors: J P Thiery; R Brackenbury; U Rutishauser; G M Edelman
Journal: J Biol Chem Date: 1977-10-10 Impact factor: 5.157

Antibody to a molecular marker of cell position inhibits synapse formation in retina.

1. DESTRUCTION OF THE SYMPATHETIC GANGLIA IN MAMMALS BY AN ANTISERUM TO A NERVE-GROWTH PROTEIN.

2. Adhesion among neural cells of the chick embryo. II. Purification and characterization of a cell adhesion molecule from neural retina.

3. Intercellular junctions in the developing neural retina of the chick embryo.

4. A topographic gradient of molecules in retina can be used to identify neuron position.

5. Antibodies to gap-junctional protein selectively disrupt junctional communication in the early amphibian embryo.

6. L1 mono- and polyclonal antibodies modify cell migration in early postnatal mouse cerebellum.

7. Inhibition of axonal growth by a monoclonal antibody.

8. Immunologic detection of retina cognin on the surface of embryonic cells.

9. Localization of alpha-bungarotoxin binding sites in synapses of the developing chick retina.

10. Immunocytochemical localization of P0 protein in Golgi complex membranes and myelin of developing rat Schwann cells.

1. Retinal engineering: engrafted neural cell lines locate in appropriate layers.

Review 2. A molecular view of vertebrate retinal development.

3. Specific adhesion between pheochromocytoma (PC12) cells and adrenal medullary endothelial cells in co-culture.