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Literature DB >> 3459147

Human Cu/Zn superoxide dismutase gene family: molecular structure and characterization of four Cu/Zn superoxide dismutase-related pseudogenes.

E Danciger, N Dafni, Y Bernstein, Z Laver-Rudich, A Neer, Y Groner.

Abstract

Four distinct human Cu/Zn superoxide dismutase (SOD1; EC 1.15.1.1)-related sequences were isolated from genomic DNA libraries. Genomic blots, heteroduplex analyses, and DNA sequencing showed that they are processed pseudogenes not residing on chromosome 21. Three of them originated from the 0.7-kilobase SOD1 mRNA, while the fourth was derived from the 0.9-kilobase mRNA species. Comparison between the coding sequences of the functional gene and two of the processed genes suggested that they integrated into the genome about 25 million years ago.

Entities: Gene Species

Mesh：

Substances：

Year: 1986 PMID： 3459147 PMCID： PMC323574 DOI： 10.1073/pnas.83.11.3619

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

22 in total

1. [Study of somatic chromosomes from 9 mongoloid children].

Authors: J LEJEUNE; M GAUTIER; R TURPIN
Journal: C R Hebd Seances Acad Sci Date: 1959-03-16

2. Copper/zinc superoxide dismutase activity in trisomy 21 by translocation.

Authors: P Garber; P M Sinet; H Jerome; J Lejeune
Journal: Lancet Date: 1979-10-27 Impact factor: 79.321

3. The evolution and sequence comparison of two recently diverged mouse chromosomal beta--globin genes.

Authors: D A Konkel; J V Maizel; P Leder
Journal: Cell Date: 1979-11 Impact factor: 41.582

4. Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing.

Authors: F Sanger; A R Coulson; B G Barrell; A J Smith; B A Roe
Journal: J Mol Biol Date: 1980-10-25 Impact factor: 5.469

5. Sequencing end-labeled DNA with base-specific chemical cleavages.

Authors: A M Maxam; W Gilbert
Journal: Methods Enzymol Date: 1980 Impact factor: 1.600

6. The evolution of genes: the chicken preproinsulin gene.

Authors: F Perler; A Efstratiadis; P Lomedico; W Gilbert; R Kolodner; J Dodgson
Journal: Cell Date: 1980-06 Impact factor: 41.582

7. The isolation and characterization of linked delta- and beta-globin genes from a cloned library of human DNA.

Authors: R M Lawn; E F Fritsch; R C Parker; G Blake; T Maniatis
Journal: Cell Date: 1978-12 Impact factor: 41.582

8. Down's syndrome as a model disease.

Authors: C H Scoggin; D Patterson
Journal: Arch Intern Med Date: 1982-03

9. Synthesis of human interferon beta 1 in Escherichia coli infected by a lambda phage recombinant containing a human genomic fragment.

Authors: Y Mory; Y Chernajovsky; S I Feinstein; L Chen; U Nir; J Weissenbach; Y Malpiece; P Tiollais; D Marks; M Ladner; C Colby; M Revel
Journal: Eur J Biochem Date: 1981-11

10. The linkage of genes for the human interferon-induced antiviral protein and indophenol oxidase-B traits to chromosome G-21.

Authors: Y H Tan; J Tischfield; F H Ruddle
Journal: J Exp Med Date: 1973-02-01 Impact factor: 14.307

5 in total

Human Cu/Zn superoxide dismutase gene family: molecular structure and characterization of four Cu/Zn superoxide dismutase-related pseudogenes.

1. [Study of somatic chromosomes from 9 mongoloid children].

2. Copper/zinc superoxide dismutase activity in trisomy 21 by translocation.

3. The evolution and sequence comparison of two recently diverged mouse chromosomal beta--globin genes.

4. Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing.

5. Sequencing end-labeled DNA with base-specific chemical cleavages.

6. The evolution of genes: the chicken preproinsulin gene.

7. The isolation and characterization of linked delta- and beta-globin genes from a cloned library of human DNA.

8. Down's syndrome as a model disease.

9. Synthesis of human interferon beta 1 in Escherichia coli infected by a lambda phage recombinant containing a human genomic fragment.

10. The linkage of genes for the human interferon-induced antiviral protein and indophenol oxidase-B traits to chromosome G-21.

1. Medical genetics in Israel.

2. The superoxide dismutase gene, a target for detection and identification of mycobacteria by PCR.

3. Deletions in processed pseudogenes accumulate faster in rodents than in humans.

Review 4. The nature of antioxidant defense mechanisms: a lesson from transgenic studies.

Review 5. Down's syndrome, neuroinflammation, and Alzheimer neuropathogenesis.