Literature DB >> 34591392

Behind the Scene: Surprises and Snags of Pseudogenes.

Hafiz Ishfaq Ahmad1, Abdul Jabbar2, Muhammad Imran3, Shakeel Ahmed4, Tanveer Majeed5, Mahmoud M Tolba6, M Mahnoor7, Hebatallah Ahmed Nasser8, Musarrat Abbas Khan9, Mario Juan Simirgiotis4.   

Abstract

The junk DNA "pseudogenes," known as genomic fossils, are characterized by their ubiquitousness and abundance within the genomic structure. These genomics sets are recognized by the potential activity of meta-regulating the parent genes; these are transcribed into interfering RNA, consequently acting on miRNA concentration, thereby shedding light on the crosstalk of the pseudogenes' miRNA, siRNA, lncRNA/tumor therapy co-relationship. Moreover, an upcoming visualization regarding pseudogenes is under investigation, which describes the potentiality of pseudogenes as a fundamental component of cancerous evolutionary processing tools. Accordingly, here is a systematic review covering pseudobirth, pseudosignatures, and functional properties of pseudogenes, concluding that these pseudogenes are hypothetically predictive tumor therapies.

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Year:  2021        PMID: 34591392     DOI: 10.1615/CritRevEukaryotGeneExpr.2021039540

Source DB:  PubMed          Journal:  Crit Rev Eukaryot Gene Expr        ISSN: 1045-4403            Impact factor:   1.807


  1 in total

1.  Structural and Evolutionary Adaptations of Nei-Like DNA Glycosylases Proteins Involved in Base Excision Repair of Oxidative DNA Damage in Vertebrates.

Authors:  Hafiz Ishfaq Ahmad; Gulnaz Afzal; Sehrish Sadia; Ghulam Haider; Shakeel Ahmed; Saba Saeed; Jinping Chen
Journal:  Oxid Med Cell Longev       Date:  2022-04-04       Impact factor: 6.543

  1 in total

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