| Literature DB >> 34591305 |
He Wang1, Qiang Zhao2.
Abstract
Bypass surgery has proven to be an effective strategy for the treatment of cardiovascular diseases. In this chapter, we describe the preparation of a type of small-diameter vascular grafts with hybrid fibrous structure by co-electrospinning. Of the two components, slow-degrading poly(ε-caprolactone) (PCL) fibers maintain the structural integrity of the graft and provide sufficient mechanical strength. The other component is rapidly degradable polymer polydioxanone (PDS) or type-I collagen that can be used as a carrier to deliver vasoactive molecules at the same time. The in vivo performance of as-prepared vascular grafts was further evaluated in a rat abdominal aorta replacement model.Entities:
Keywords: Co-electrospinning; Rapid degradation; Rat abdominal aorta replacement model; Tissue-engineered vascular grafts (TEVGs); Vasoactive molecules
Mesh：
Substances：
Year: 2022 PMID： 34591305 DOI： 10.1007/978-1-0716-1708-3_12
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745