| Literature DB >> 34590972 |
Xue-Ming Wu1, Guan-Cheng Dai1, Bei-Bei Zhou1, Yong Chen1, Ren-Xiang Tan1,2.
Abstract
Three new polyketide derivatives, 2-ethoxycarbonyl-endocrocin (1), 6-methoxy-2-ethoxycarbonyl-endocrocin (2) and pannorin C (3), along with sixteen known compounds (4-19) were isolated from a plant endophytic fungus Aspergillus cristatus 2H1. Their structures were elucidated by 1D/2D NMR and HR-ESI-MS data analysis. Compound 3 showed weak antibacterial activity against Staphylococcus aureus (MIC 20 μg/ml). Compounds 14 and 15 showed effective cytotoxicity on human melanoma A375 cells (IC50 4.13 μM for 14, 3.39 μM for 15).Entities:
Keywords: Aspergillus cristatus; antibacterial activity; antitumoral activity; polyketide derivatives
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Year: 2021 PMID： 34590972 DOI： 10.1080/10286020.2021.1972982
Source DB: PubMed Journal: J Asian Nat Prod Res ISSN： 1028-6020 Impact factor: 1.610