Literature DB >> 34590632

Zn2+-Dependent peptide nucleic acid-based artificial ribonucleases with unprecedented efficiency and specificity.

Olivia Luige1, Partha Pratim Bose1, Rouven Stulz1,2,3, Peter Steunenberg1, Omar Brun1, Shalini Andersson2, Merita Murtola1, Roger Strömberg1.   

Abstract

We present Zn2+-dependent dimethyl-dipyridophenazine PNA conjugates as efficient RNA cleaving artificial enzymes. These PNAzymes display site-specific RNA cleavage with 10 minute half-lives and cleave clinically relevant RNA models.

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Year:  2021        PMID： 34590632     DOI： 10.1039/d1cc04383h

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  2 in total

1.  Enzymatic Synthesis of Chemical Nuclease Triplex-Forming Oligonucleotides with Gene-Silencing Applications.

Authors:  Bríonna McGorman; Nicolò Zuin Fantoni; Sinéad O'Carroll; Anna Ziemele; Afaf H El-Sagheer; Tom Brown; Andrew Kellett
Journal:  Nucleic Acids Res       Date:  2022-06-10       Impact factor: 19.160

2.  Influence of sequence variation on the RNA cleavage activity of Zn2+-dimethyl-dppz-PNA-based artificial enzymes.

Authors:  Olivia Luige; Kristina Karalė; Partha Pratim Bose; Martin Bollmark; Ulf Tedebark; Merita Murtola; Roger Strömberg
Journal:  RSC Adv       Date:  2022-02-14       Impact factor: 3.361
  2 in total

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