| Literature DB >> 34590262 |
Ashelyn E Sidders1, Lauren C Radlinski1, Sarah E Rowe1, Brian P Conlon2,3.
Abstract
Aminoglycosides are bactericidal drugs which require a proton motive force (PMF) for uptake into the bacterial cell. Low energy cells, such as persisters, maintain a PMF below the threshold for drug uptake and are tolerant to aminoglycosides. In this chapter, we discuss mechanisms to target the bacterial membrane and stimulate aminoglycoside uptake to kill Staphylococcus aureus persisters.Entities:
Keywords: Adjuvants; Aminoglycosides; Persisters; Staphylococcus aureus; Synergy
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Year: 2021 PMID： 34590262 DOI： 10.1007/978-1-0716-1621-5_15
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745