Sally A Amundson1. 1. Center for Radiological Research, Columbia University Irving Medical Center, New York, NY, USA.
Abstract
PURPOSE: This article will briefly review the origins and evolution of functional genomics, first describing the experimental technology, and then some of the approaches applied to data analysis and visualization. It will emphasize application of functional genomics to radiation biology, using examples from the author's work to illustrate several key types of analysis. It concludes with a look at non-coding RNA, alternative reading of the genome, and single-cell transcriptomics, some of the innovative areas that may help to shape future research in radiation biology and oncology. CONCLUSIONS: Transcriptomic approaches have provided insight into many areas of radiation biology and medicine, and innovations in technology and data analysis approaches promise continued contributions to radiation science in the future.
PURPOSE: This article will briefly review the origins and evolution of functional genomics, first describing the experimental technology, and then some of the approaches applied to data analysis and visualization. It will emphasize application of functional genomics to radiation biology, using examples from the author's work to illustrate several key types of analysis. It concludes with a look at non-coding RNA, alternative reading of the genome, and single-cell transcriptomics, some of the innovative areas that may help to shape future research in radiation biology and oncology. CONCLUSIONS: Transcriptomic approaches have provided insight into many areas of radiation biology and medicine, and innovations in technology and data analysis approaches promise continued contributions to radiation science in the future.
Authors: Marshleen Yadav; Sagar Bhayana; Joseph Liu; Lanchun Lu; Jason Huang; Ya Ma; Zahida Qamri; Xiaokui Mo; Diviya S Jacob; Shashaank T Parasa; Noureen Bhuiya; Paolo Fadda; Meng Xu-Welliver; Arnab Chakravarti; Naduparambil K Jacob Journal: Sci Transl Med Date: 2020-07-15 Impact factor: 17.956
Authors: Sally A Amundson; Khanh T Do; Lisa C Vinikoor; R Anthony Lee; Christine A Koch-Paiz; Jaeyong Ahn; Mark Reimers; Yidong Chen; Dominic A Scudiero; John N Weinstein; Jeffrey M Trent; Michael L Bittner; Paul S Meltzer; Albert J Fornace Journal: Cancer Res Date: 2008-01-15 Impact factor: 12.701
Authors: Ellina Macaeva; Yvan Saeys; Kevin Tabury; Ann Janssen; Arlette Michaux; Mohammed A Benotmane; Winnok H De Vos; Sarah Baatout; Roel Quintens Journal: Sci Rep Date: 2016-01-14 Impact factor: 4.379
Authors: Daniel C Berrios; Jonathan Galazka; Kirill Grigorev; Samrawit Gebre; Sylvain V Costes Journal: Nucleic Acids Res Date: 2021-01-08 Impact factor: 16.971