BACKGROUND: For unvaccinated individuals with mild-to-moderate coronavirus disease 2019 (COVID-19), monoclonal antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) decrease the risk of severe disease and hospitalization. We describe the use of the monoclonal antibodies casirivimab and imdevimab for COVID-19 in pregnancy. CASE: Two unvaccinated pregnant individuals presented with moderate COVID-19, one in the second trimester and one in third trimester; both met criteria for outpatient management. To decrease the risk for severe disease, they were treated with casirivimab and imdevimab. Neither experienced an adverse drug reaction, and neither progressed to severe disease. CONCLUSION: Monoclonal antibodies such as casirivimab and imdevimab, approved under an emergency use authorization, should be considered in unvaccinated pregnant individuals with mild-to-moderate COVID-19 to decrease the risk of severe disease.
BACKGROUND: For unvaccinated individuals with mild-to-moderate coronavirus disease 2019 (COVID-19), monoclonal antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) decrease the risk of severe disease and hospitalization. We describe the use of the monoclonal antibodies casirivimab and imdevimab for COVID-19 in pregnancy. CASE: Two unvaccinated pregnant individuals presented with moderate COVID-19, one in the second trimester and one in third trimester; both met criteria for outpatient management. To decrease the risk for severe disease, they were treated with casirivimab and imdevimab. Neither experienced an adverse drug reaction, and neither progressed to severe disease. CONCLUSION: Monoclonal antibodies such as casirivimab and imdevimab, approved under an emergency use authorization, should be considered in unvaccinated pregnant individuals with mild-to-moderate COVID-19 to decrease the risk of severe disease.
Authors: Mei H Chang; Kelsie Cowman; Yi Guo; Hongkai Bao; Peter S Bernstein; Inessa Gendlina; Priya Nori Journal: Am J Obstet Gynecol Date: 2022-01-21 Impact factor: 10.693
Authors: A García-Lledó; J Gómez-Pavón; J González Del Castillo; T Hernández-Sampelayo; M C Martín-Delgado; F J Martín Sánchez; M Martínez-Sellés; J M Molero García; S Moreno Guillén; F J Rodríguez-Artalejo; J Ruiz-Galiana; R Cantón; P De Lucas Ramos; A García-Botella; E Bouza Journal: Rev Esp Quimioter Date: 2021-12-11 Impact factor: 1.553
Authors: Maria Mupanomunda; Mohamad G Fakih; Collin Miller; Allison Ottenbacher; Angela L Winegar; Phillip Roberts; Moyo Kimathi; John G Gianopoulos; Alison G Cahill; Joseph G Cacchione; Richard I Fogel; Thomas A Aloia; Frederick A Masoudi Journal: JAMA Netw Open Date: 2022-08-01