Ettie M Lipner1,2, Joshua P French3, Joseph O Falkinham4, James L Crooks5,2, Rachel A Mercaldo6, Emily Henkle7, D Rebecca Prevots8. 1. Integrated Center for Genes, Environment and Health, and. 2. Department of Epidemiology, Colorado School of Public Health, Aurora, Colorado. 3. Department of Mathematical and Statistical Sciences, University of Colorado Denver, Denver, Colorado. 4. Virginia Tech, Blacksburg, Virginia. 5. Division of Biostatistics and Bioinformatics, National Jewish Health, Denver, Colorado. 6. Department of Epidemiology and Biostatistics, University of Georgia, Atlanta, Georgia. 7. OHSU-PSU School of Public Health, Oregon Health & Science University, Portland, Oregon; and. 8. National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
Abstract
Rationale: Nontuberculous mycobacteria (NTM) are ubiquitous environmental bacteria, and some pathogenic species cause lung disease. Environmental factors contribute to increased NTM abundance, with higher potential for exposure and infection. Objectives: To identify water-quality constituents that influence the risk of NTM infection in Oregon. Methods: We conducted a population-based cohort study using patient incidence data from the Oregon statewide NTM laboratory data collected as part of a public health surveillance project from 2007 through 2012. To estimate the risk of NTM pulmonary infection (PI) from exposure to water constituents, we extracted water-quality data from the Water Quality Portal and associated these data with corresponding patient county of residence. Using generalized linear models, we modeled two outcomes: Mycobacterium avium complex species PI and Mycobacterium abscessus group species PI. Results: For every 1-unit increase in the log concentration of vanadium in surface water, infection risk increased by 49% among persons with Mycobacterium avium complex PI. Among those with Mycobacterium abscessus PI, we observed that for every 1-unit increase in the log concentration of molybdenum in surface water, infection risk increased by 41%. The highest risk of infection due to Mycobacterium abscessus group infection was concentrated in counties within the Northwestern region of Oregon. High infection risk associated with Mycobacterium avium complex species did not show any geographic pattern. Conclusions: Concentrations of the trace metals molybdenum and vanadium in surface water sources were associated with NTM infection in Oregon. These findings may help identify regions at higher risk of NTM infection to guide risk reduction strategies.
Rationale: Nontuberculous mycobacteria (NTM) are ubiquitous environmental bacteria, and some pathogenic species cause lung disease. Environmental factors contribute to increased NTM abundance, with higher potential for exposure and infection. Objectives: To identify water-quality constituents that influence the risk of NTM infection in Oregon. Methods: We conducted a population-based cohort study using patient incidence data from the Oregon statewide NTM laboratory data collected as part of a public health surveillance project from 2007 through 2012. To estimate the risk of NTM pulmonary infection (PI) from exposure to water constituents, we extracted water-quality data from the Water Quality Portal and associated these data with corresponding patient county of residence. Using generalized linear models, we modeled two outcomes: Mycobacterium avium complex species PI and Mycobacterium abscessus group species PI. Results: For every 1-unit increase in the log concentration of vanadium in surface water, infection risk increased by 49% among persons with Mycobacterium avium complex PI. Among those with Mycobacterium abscessus PI, we observed that for every 1-unit increase in the log concentration of molybdenum in surface water, infection risk increased by 41%. The highest risk of infection due to Mycobacterium abscessus group infection was concentrated in counties within the Northwestern region of Oregon. High infection risk associated with Mycobacterium avium complex species did not show any geographic pattern. Conclusions: Concentrations of the trace metals molybdenum and vanadium in surface water sources were associated with NTM infection in Oregon. These findings may help identify regions at higher risk of NTM infection to guide risk reduction strategies.
Authors: Jerry A Nick; D Rebecca Prevots; Ettie M Lipner; James L Crooks; Joshua French; Michael Strong Journal: J Expo Sci Environ Epidemiol Date: 2021-07-03 Impact factor: 5.563
Authors: Ettie M Lipner; Joshua French; Carleton R Bern; Katherine Walton-Day; David Knox; Michael Strong; D Rebecca Prevots; James L Crooks Journal: Int J Environ Res Public Health Date: 2020-05-29 Impact factor: 3.390
Authors: Ettie M Lipner; Joshua P French; Stephen Nelson; Joseph O Falkinham Iii; Rachel A Mercaldo; Rebekah A Blakney; Yihe G Daida; Timothy B Frankland; Kyle P Messier; Jennifer R Honda; Stacey Honda; D Rebecca Prevots Journal: Environ Epidemiol Date: 2022-09-02