| Literature DB >> 34582201 |
Daniel Szczerba1, Davin Tan2, Jean-Louis Do2, Hatem M Titi2, Siham Mouhtadi3, Denis Chaumont1, María Del Carmen Marco de Lucas1, Nicolas Geoffroy1, Michel Meyer4, Yoann Rousselin4, Jessica M Hudspeth5, Valérie Schwanen6, Petra Spoerk-Erdely7, Ann-Christin Dippel8, Oleh Ivashko8, Olof Gutowski8, Philipp Glaevecke8, Vasilii Bazhenov9, Mihails Arhangelskis10, Ivan Halasz11, Tomislav Friščić2, Simon A J Kimber1.
Abstract
Colloidal bismuth therapeutics have been used for hundreds of years, yet remain mysterious. Here we report an X-ray pair distribution function (PDF) study of the solvolysis of bismuth disalicylate, a model for the metallodrug bismuth subsalicylate (Pepto-Bismol). This reveals catalysis by traces of water, followed by multistep cluster growth. The ratio of the two major species, {Bi9O7} and {Bi38O44}, depends on exposure to air, time, and the solvent. The solution-phase cluster structures are of significantly higher symmetry in comparison to solid-state analogues, with reduced off-center Bi3+ displacements. This explains why such "magic-size" clusters can be both stable enough to crystallize and sufficiently labile for further growth.Entities:
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Year: 2021 PMID： 34582201 DOI： 10.1021/jacs.1c07186
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419