| Literature DB >> 34581882 |
Yixuan Wang1,2, Si Zhang1,2, Qian Sun1,2, Fan'en Yuan1,2, Linyao Zhao1,2, Zhang Ye1,2, Yong Li1,2, Ronggui Wang1,2, Hongxiang Jiang1,2, Ping Hu1,2, Daofeng Tian3,4, Baohui Liu5,6.
Abstract
WAC is closely related to the occurrence and development of tumors. However, its role in human glioblastoma (GBM) and its potential regulatory mechanisms have not been investigated. This study demonstrated that WAC is downregulated in GBM, and its low expression predicts a poor prognosis. We investigated the effect of WAC on the proliferation of glioma cells through a CCK-8 assay, EdU incorporation, and cell formation. The effects of WAC on apoptosis and autophagy in glioma were determined by flow cytometry, TUNEL detection, immunofluorescence, q-PCR, WB, and scanning electron microscopy. We found that overexpression of WAC inhibited the proliferation of glioma cells, promoted apoptosis, and induced autophagy. Therefore, WAC is likely to play a role as a new regulatory molecule in glioma.Entities:
Keywords: Apoptosis; Autophagy; GBM; Proliferation; WAC
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Year: 2021 PMID： 34581882 DOI： 10.1007/s12032-021-01580-0
Source DB: PubMed Journal: Med Oncol ISSN： 1357-0560 Impact factor: 3.064