Merel Ritskes-Hoitinga1,2, Wynand Alkema3,4. 1. SYRCLE, Department for Health Evidence, 221034Radboudumc, Nijmegen, the Netherlands. 2. AUGUST, Department for Clinical Medicine, Aarhus University, Aarhus, Denmark. 3. Institute for Life Science and Technology, 3645Hanze University of Applied Sciences, Groningen, the Netherlands. 4. TenWise BV, Oss, the Netherlands.