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Literature DB >> 34580036

Targeting the mitochondrial unfolded protein response in cancer: opportunities and challenges.

Joseph R Inigo¹, Rahul Kumar¹, Dhyan Chandra².

Abstract

Increasing evidence indicates that a mitochondria-specific stress response referred to as the 'mitochondrial unfolded protein response' (UPRmt) is activated to maintain mitochondrial integrity and support tumor growth. In this forum article, we discuss the recent advances and current challenges in therapeutically targeting UPRmt in cancer.

Entities: Chemical

Keywords: cancer; mitochondrial chaperonins; mitochondrial proteases; mitochondrial proteostasis; mitochondrial unfolded protein response

Mesh：

Year: 2021 PMID： 34580036 PMCID： PMC9287746 DOI： 10.1016/j.trecan.2021.08.008

Source DB: PubMed Journal: Trends Cancer ISSN： 2405-8025

15 in total

1. Population pharmacokinetics of higher-dose mizoribine in healthy male volunteers.

Authors: Mutsuko Honda; Hiromichi Itoh; Tadakiyo Suzuki; Yukiya Hashimoto
Journal: Biol Pharm Bull Date: 2006-12 Impact factor: 2.233

Review 2. The multifaceted contributions of mitochondria to cellular metabolism.

Authors: Jessica B Spinelli; Marcia C Haigis
Journal: Nat Cell Biol Date: 2018-06-27 Impact factor: 28.824

3. Exploration of Benzothiazole Rhodacyanines as Allosteric Inhibitors of Protein-Protein Interactions with Heat Shock Protein 70 (Hsp70).

Authors: Hao Shao; Xiaokai Li; Michael A Moses; Luke A Gilbert; Chakrapani Kalyanaraman; Zapporah T Young; Margarita Chernova; Sara N Journey; Jonathan S Weissman; Byron Hann; Matthew P Jacobson; Len Neckers; Jason E Gestwicki
Journal: J Med Chem Date: 2018-07-13 Impact factor: 7.446

Review 4. Mitochondrial dysfunction in cancer: Potential roles of ATF5 and the mitochondrial UPR.

Authors: Pan Deng; Cole M Haynes
Journal: Semin Cancer Biol Date: 2017-05-10 Impact factor: 15.707

5. Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid Leukemia.

Authors: Alicia Cole; Zezhou Wang; Etienne Coyaud; Veronique Voisin; Marcela Gronda; Yulia Jitkova; Rachel Mattson; Rose Hurren; Sonja Babovic; Neil Maclean; Ian Restall; Xiaoming Wang; Danny V Jeyaraju; Mahadeo A Sukhai; Swayam Prabha; Shaheena Bashir; Ashwin Ramakrishnan; Elisa Leung; Yi Hua Qia; Nianxian Zhang; Kevin R Combes; Troy Ketela; Fengshu Lin; Walid A Houry; Ahmed Aman; Rima Al-Awar; Wei Zheng; Erno Wienholds; Chang Jiang Xu; John Dick; Jean C Y Wang; Jason Moffat; Mark D Minden; Connie J Eaves; Gary D Bader; Zhenyue Hao; Steven M Kornblau; Brian Raught; Aaron D Schimmer
Journal: Cancer Cell Date: 2015-06-08 Impact factor: 31.743

6. A Synthetic Cell-Penetrating Dominant-Negative ATF5 Peptide Exerts Anticancer Activity against a Broad Spectrum of Treatment-Resistant Cancers.

Authors: Georg Karpel-Massler; Basil A Horst; Chang Shu; Lily Chau; Takashi Tsujiuchi; Jeffrey N Bruce; Peter Canoll; Lloyd A Greene; James M Angelastro; Markus D Siegelin
Journal: Clin Cancer Res Date: 2016-04-28 Impact factor: 12.531

7. The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPR.

Authors: Christopher J Fiorese; Anna M Schulz; Yi-Fan Lin; Nadine Rosin; Mark W Pellegrino; Cole M Haynes
Journal: Curr Biol Date: 2016-07-14 Impact factor: 10.834

8. Anticancer Gold(III) Porphyrins Target Mitochondrial Chaperone Hsp60.

Authors: Di Hu; Yungen Liu; Yau-Tsz Lai; Ka-Chung Tong; Yi-Man Fung; Chun-Nam Lok; Chi-Ming Che
Journal: Angew Chem Int Ed Engl Date: 2015-12-09 Impact factor: 15.336

9. Dominant-Negative ATF5 Compromises Cancer Cell Survival by Targeting CEBPB and CEBPD.

Authors: Xiaotian Sun; Parvaneh Jefferson; Qing Zhou; James M Angelastro; Lloyd A Greene
Journal: Mol Cancer Res Date: 2019-11-01 Impact factor: 5.852

10. Targeting mitochondria as an anticancer strategy.

Authors: Lanfeng Dong; Jiri Neuzil
Journal: Cancer Commun (Lond) Date: 2019-10-25

1 in total

1. A mitochondrial unfolded protein response inhibitor suppresses prostate cancer growth in mice via HSP60.

Authors: Rahul Kumar; Ajay K Chaudhary; Jordan Woytash; Joseph R Inigo; Abhiram A Gokhale; Wiam Bshara; Kristopher Attwood; Jianmin Wang; Joseph A Spernyak; Eva Rath; Neelu Yadav; Dirk Haller; David W Goodrich; Dean G Tang; Dhyan Chandra
Journal: J Clin Invest Date: 2022-07-01 Impact factor: 19.456

1 in total