Alex P Tannenbaum1, Matthew D Grimes2, Christopher L Brace3, Cody J Johnson4, Samuel D Koebe1, Lucille E Anzia5, Lu Mao6, William A Ricke7, Diego Hernando8, Alejandro Roldan-Alzate4, Shane A Wells9. 1. University of Wisconsin School of Medicine and Public Heath, Madison, WI. 2. Department of Urology, University of Wisconsin, Madison, WI. 3. Department of Radiology, University of Wisconsin, Madison, WI; Department of Biomedical Engineering, University of Wisconsin, Madison, WI. 4. Department of Radiology, University of Wisconsin, Madison, WI; Department of Mechanical Engineering, University of Wisconsin, Madison, WI. 5. College of Medicine, University of Central Florida, Orlando, FL. 6. Department of Biostatistics and Medical Informatics, University of Wisconsin, Madison, WI. 7. Department of Urology, University of Wisconsin, Madison, WI; George M. O'Brien Center of Research Excellence, University of Wisconsin, Madison, WI. 8. Department of Radiology, University of Wisconsin, Madison, WI; Department of Medical Physics, University of Wisconsin, Madison, WI. 9. Department of Radiology, University of Wisconsin, Madison, WI. Electronic address: sawells@wisc.edu.
Abstract
OBJECTIVE: To investigate the relationship between metabolic syndrome (MetS) and lower urinary tract symptoms (LUTS) with functional and anatomic changes of the lower urinary tract with MRI. MATERIALS AND METHODS: The bladder and prostate of 95 subjects (56M, 39F) were segmented on T2-weighted pelvic MRI using Materialize Mimics 3D software. Bladder wall volume (BWV), post-void residual (PVR) and prostate volume (PV) were quantified from the 3D renderings. LUTS were quantified using validated questionnaires administered at the time of MRI. Wilcoxin rank sum, win ratio and chi-square tests were used to correlate symptom scores, BWV, PVR and PV in patients 1) without vs with MetS, 2) with mild (IPSS or UDI-6: 0-7) vs moderate-severe (IPSS: 8-35 or UDI-6: ≥8) and 3) normal vs enlarged prostates (>40cm3). Multivariate linear regression was used to determine predictors for BWV, PVR and PV. RESULTS: Men with MetS had increased BWV (66.8 vs 51.1cm3, P = .003), higher PVR (69.1 vs 50.5cc, P= .05) and increased PV (67.2 vs 40.1cm3, P= .01). Women without and with MetS had similar BWV, PVR and LUTS (P= .3-.78). There was no difference in prevalence of MetS, BWV, PVR or PV in men or women with mild vs moderate-severe LUTS (P = .26-.97). Men with enlarged prostates were more likely to have MetS (P = .003). There was no difference in BWV, PVR and LUTS for men with normal vs enlarged prostates (P= .44-.94). In men, BWV was highly correlated with MetS (P = .005) on regression analysis. CONCLUSION: MetS leads to detrusor hypertrophy and may contribute to impaired bladder function, likely related to the effect on the prostate.
OBJECTIVE: To investigate the relationship between metabolic syndrome (MetS) and lower urinary tract symptoms (LUTS) with functional and anatomic changes of the lower urinary tract with MRI. MATERIALS AND METHODS: The bladder and prostate of 95 subjects (56M, 39F) were segmented on T2-weighted pelvic MRI using Materialize Mimics 3D software. Bladder wall volume (BWV), post-void residual (PVR) and prostate volume (PV) were quantified from the 3D renderings. LUTS were quantified using validated questionnaires administered at the time of MRI. Wilcoxin rank sum, win ratio and chi-square tests were used to correlate symptom scores, BWV, PVR and PV in patients 1) without vs with MetS, 2) with mild (IPSS or UDI-6: 0-7) vs moderate-severe (IPSS: 8-35 or UDI-6: ≥8) and 3) normal vs enlarged prostates (>40cm3). Multivariate linear regression was used to determine predictors for BWV, PVR and PV. RESULTS: Men with MetS had increased BWV (66.8 vs 51.1cm3, P = .003), higher PVR (69.1 vs 50.5cc, P= .05) and increased PV (67.2 vs 40.1cm3, P= .01). Women without and with MetS had similar BWV, PVR and LUTS (P= .3-.78). There was no difference in prevalence of MetS, BWV, PVR or PV in men or women with mild vs moderate-severe LUTS (P = .26-.97). Men with enlarged prostates were more likely to have MetS (P = .003). There was no difference in BWV, PVR and LUTS for men with normal vs enlarged prostates (P= .44-.94). In men, BWV was highly correlated with MetS (P = .005) on regression analysis. CONCLUSION: MetS leads to detrusor hypertrophy and may contribute to impaired bladder function, likely related to the effect on the prostate.
Authors: Baris Turkbey; Sergei V Fotin; Robert J Huang; Yin Yin; Dagane Daar; Omer Aras; Marcelino Bernardo; Brian E Garvey; Juanita Weaver; Hrishikesh Haldankar; Naira Muradyan; Maria J Merino; Peter A Pinto; Senthil Periaswamy; Peter L Choyke Journal: AJR Am J Roentgenol Date: 2013-11 Impact factor: 3.959
Authors: Mauro Gacci; Giovanni Corona; Linda Vignozzi; Matteo Salvi; Sergio Serni; Cosimo De Nunzio; Andrea Tubaro; Matthias Oelke; Marco Carini; Mario Maggi Journal: BJU Int Date: 2014-08-16 Impact factor: 5.588