Literature DB >> 3456987

[Ofloxacin in the conservative therapy of acute and chronic otitis media--a preliminary clinical report of experiences].

T Lenarz.   

Abstract

After ascertaining the bacterial spectrum in 105 patients with Otitis media acutissima, Otitis media chronica mesotympanalis and Otitis media chronica epitympanalis, the efficacy of oral therapy with ofloxacin in five patients from each of these groups was assessed. The results are comparable with those following conventional local and intravenous antibiotic therapy. On the basis of these preliminary results, ofloxacin can be considered as a highly efficient oral substance which is effective against Staphylococcus aureus and Pseudomonas aeruginosa, two important pathogens in inflammatory ear infections.

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Year:  1986        PMID: 3456987     DOI: 10.1007/BF01645208

Source DB:  PubMed          Journal:  Infection        ISSN: 0300-8126            Impact factor:   3.553


  1 in total

1.  Microbiology of otitis media.

Authors:  J O Klein
Journal:  Ann Otol Rhinol Laryngol Suppl       Date:  1980 May-Jun
  1 in total
  6 in total

Review 1.  Ofloxacin. A reappraisal of its antimicrobial activity, pharmacology and therapeutic use.

Authors:  P A Todd; D Faulds
Journal:  Drugs       Date:  1991-11       Impact factor: 9.546

2.  Concentrations of ofloxacin in ear and nasal tissues.

Authors:  P Tolsdorff
Journal:  Eur Arch Otorhinolaryngol       Date:  1993       Impact factor: 2.503

3.  Ofloxacin in oral chemotherapy of acute and chronic otitis media.

Authors:  T Lenarz
Journal:  Infection       Date:  1986       Impact factor: 3.553

Review 4.  Ofloxacin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use.

Authors:  J P Monk; D M Campoli-Richards
Journal:  Drugs       Date:  1987-04       Impact factor: 9.546

5.  Tissue and serum concentrations of ofloxacin in the ear region following a single daily oral dose of 400 mg.

Authors:  P Tolsdorff
Journal:  Infection       Date:  1993 Jan-Feb       Impact factor: 3.553

6.  Chemotherapy of otitis media with ofloxacin.

Authors:  T Lenarz
Journal:  Drugs       Date:  1987       Impact factor: 9.546

  6 in total

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