Gulten Ozturk1, Dilşad Turkdogan2, Olcay Unver2, Volkan Dericioglu3, Bulent Aslan4, Adnan Dagcinar5. 1. Department of Pediatric Neurology, Marmara University Medical Faculty Pendik Education and Research Hospital, Istanbul, Turkey. gulten@thomas.md. 2. Department of Pediatric Neurology, Marmara University Medical Faculty Pendik Education and Research Hospital, Istanbul, Turkey. 3. Department of Ophtalmology, Marmara University Pendik Education and Research Hospital, Istanbul, Turkey. 4. Department of Radiology, Marmara University Pendik Education and Research Hospital, Istanbul, Turkey. 5. Department of Neurosurgery, Marmara University Medical Faculty Pendik Education and Research Hospital, Istanbul, Turkey.
Abstract
BACKGROUND: Diagnosis and treatment of pseudotumor cerebri syndrome in children is still a challenge for clinicians. The aim of this study is to reveal the influence of presentation age and CSF opening pressure on long-term prognosis of pseudotumor cerebri and share our clinical data of the very young age (≤ 5-year) group. METHOD: This retrospective study includes the patients followed by the Marmara University Pediatric Neurology Clinic between years 2012 and 2020 diagnosed with definite, probable, or suggestive pseudotumor cerebri syndrome according to modified Friedman criteria. Patients were classified into three groups according to presentation age: group 1: ≤ 5 years old; group 2: 6-10 years; and group 3 > 10 years old. CSF opening pressure was also categorized into three groups as CSF < 20 cmH20; CSF 20-30 cmH20; and CSF > 30 cmH20. RESULTS: One hundred three patients, 62.1% female (n = 64), were enrolled in the study. Group 1 consisted of 16 patients (60% male), group 2 consisted of 30 patients (63.3% female), and group 3 consisted of 57 patients (66.7% female). The mean CSF opening pressure did not differ between the three age groups in our study (p > 0.05). Treatment response was not correlated with CSF opening pressure. Papilledema presence and level of CSF opening pressure were independent of age (p > 0.05). CONCLUSIONS: Age at presentation and CSF opening pressure at diagnosis are not any predictive factors that influence long-term prognosis of pseudotumor cerebri syndrome in children. Evaluation and follow-up of children should be done in personalized approach.
BACKGROUND: Diagnosis and treatment of pseudotumor cerebri syndrome in children is still a challenge for clinicians. The aim of this study is to reveal the influence of presentation age and CSF opening pressure on long-term prognosis of pseudotumor cerebri and share our clinical data of the very young age (≤ 5-year) group. METHOD: This retrospective study includes the patients followed by the Marmara University Pediatric Neurology Clinic between years 2012 and 2020 diagnosed with definite, probable, or suggestive pseudotumor cerebri syndrome according to modified Friedman criteria. Patients were classified into three groups according to presentation age: group 1: ≤ 5 years old; group 2: 6-10 years; and group 3 > 10 years old. CSF opening pressure was also categorized into three groups as CSF < 20 cmH20; CSF 20-30 cmH20; and CSF > 30 cmH20. RESULTS: One hundred three patients, 62.1% female (n = 64), were enrolled in the study. Group 1 consisted of 16 patients (60% male), group 2 consisted of 30 patients (63.3% female), and group 3 consisted of 57 patients (66.7% female). The mean CSF opening pressure did not differ between the three age groups in our study (p > 0.05). Treatment response was not correlated with CSF opening pressure. Papilledema presence and level of CSF opening pressure were independent of age (p > 0.05). CONCLUSIONS: Age at presentation and CSF opening pressure at diagnosis are not any predictive factors that influence long-term prognosis of pseudotumor cerebri syndrome in children. Evaluation and follow-up of children should be done in personalized approach.
Authors: Gabriela G M Balbi; Sandro L Matas; Claudio A Len; Melissa M Fraga; Iggor O Sousa; Maria Teresa Terreri Journal: Arq Neuropsiquiatr Date: 2018-11 Impact factor: 1.420
Authors: Michael Wall; Michael P McDermott; Karl D Kieburtz; James J Corbett; Steven E Feldon; Deborah I Friedman; David M Katz; John L Keltner; Eleanor B Schron; Mark J Kupersmith Journal: JAMA Date: 2014 Apr 23-30 Impact factor: 56.272
Authors: Claire A Sheldon; Grace L Paley; Shannon J Beres; Shana E McCormack; Grant T Liu Journal: Semin Pediatr Neurol Date: 2017-04-07 Impact factor: 1.636
Authors: Anita A Kohli; Arastoo Vossough; Robert M Mallery; John H Woo; Claire A Sheldon; Grace L Paley; Kathleen B Digre; Deborah I Friedman; John T Farrar; Shana E McCormack; Grant T Liu; Christina L Szperka Journal: Pediatr Neurol Date: 2019-05-17 Impact factor: 3.372
Authors: Hüseyin Per; Mehmet Canpolat; Hakan Gümüş; Hatice Gamze Poyrazoğlu; Ali Yıkılmaz; Sarper Karaküçük; Hakkı Doğan; Sefer Kumandaş Journal: Brain Dev Date: 2012-09-13 Impact factor: 1.961
Authors: Susan P Mollan; Keira A Markey; James D Benzimra; Andrew Jacks; Tim D Matthews; Michael A Burdon; Alex J Sinclair Journal: Pract Neurol Date: 2014-05-08