Literature DB >> 3456891

The influence of isotopic and nonisotopic carriers on the biodistribution and biokinetics of M3+-citrate complexes.

K Schomäcker, W G Franke, E Henke, W D Fromm, G Maka, G J Beyer.   

Abstract

The influence of carrier amounts of Fe, Ga, and Tm on the biodistribution of 67Ga-, 59Fe-, and 167Tm-citrate in mice was investigated. Our results suggest that 167Tm, unlike 67Ga and 59Fe, is not transported by transferrin in the blood. Of the three radioisotopes tested, 167Tm had the highest tumor/background ratio (10 h after the injection). The application of Fe carrier led to an enhancement of the elimination of 67Ga from the blood and muscles, resulting in a better tumor/background ratio.

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Year:  1986        PMID： 3456891     DOI： 10.1007/BF00253299

Source DB:  PubMed          Journal:  Eur J Nucl Med        ISSN： 0340-6997


  26 in total

1.  Formation constants of gallium- and indium-transferrin.

Authors:  S Kulprathipanja; D J Hnatowich; R Beh; D Elmaleh
Journal:  Int J Nucl Med Biol       Date:  1979

2.  The stability constants of the iron-transferrin complex.

Authors:  B DAVIS; P SALTMAN; S BENSON
Journal:  Biochem Biophys Res Commun       Date:  1962-06-19       Impact factor: 3.575

3.  The behaviour of tracer gallium-67 towards serum proteins.

Authors:  S W Gunasekera; L J King; P J Lavender
Journal:  Clin Chim Acta       Date:  1972-07       Impact factor: 3.786

4.  [Examination of the kinetics of 167thulium with respect to its tumour affinity (author's transl)].

Authors:  W G Franke; K Hennig; G J Beyer; E Henke; V A Khalkin
Journal:  Radiobiol Radiother (Berl)       Date:  1979-06

5.  Relationships between the metabolism of 67 Ga and iron.

Authors:  R Sephton
Journal:  Int J Nucl Med Biol       Date:  1981

6.  The role of transferrins in gallium uptake.

Authors:  S M Larson; Z Grunbaum; J S Rasey
Journal:  Int J Nucl Med Biol       Date:  1981

7.  Mechanisms of distribution of gallium 67 in mouse tumour hosts.

Authors:  R G Sephton; S De Abrew; G S Hodgson
Journal:  Br J Radiol       Date:  1982-02       Impact factor: 3.039

8.  Tumor uptake of high and low molecular weight fractions from 67Ga-citrate labelled blood plasma.

Authors:  L J Anghileri; M C Crone; P Thouvenot; F Brunotte; C Marchal; J Robert
Journal:  Nuklearmedizin       Date:  1984-04       Impact factor: 1.379

9.  Studies of the in vivo entry of Ga-67 into normal and malignant tissue.

Authors:  R L Hayes; J J Rafter; B L Byrd; J E Carlton
Journal:  J Nucl Med       Date:  1981-04       Impact factor: 10.057

10.  Effect of desferoxamine on tissue and tumor retention of gallium-67: concise communication.

Authors:  P B Hoffer; A Samuel; J T Bushberg; M Thakur
Journal:  J Nucl Med       Date:  1979-03       Impact factor: 10.057
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