| Literature DB >> 34567487 |
Lingmin Huang1, Jianrong Guo1, Bo Yin1, Yanqing Zeng1, Na Li2.
Abstract
This paper mainly analyzes the feasibility of laparoscopic local gastrectomy for the treatment of benign gastric tumors, evaluating its curative effect, and the use of traditional Chinese medicine (TCM) such as Hedyotis diffusa, Radix Pseudostellariae, yi, Pinellia ternata, Ophiopogon japonicus, wood fragrance, Perilla, Scutellaria baicalensis, Yuzhu, hawthorn, Artemisia annua, chicken yellow film, nail, and turtle, and clinical symptoms of statistical analysis of data mining. A total of 86 patients with gastric benign tumor were selected as the research object and were divided into observation group and control group with 43 cases in each by the random number table method. The control group received radical gastrectomy for benign tumor under laparoscopy, while the observation group received local gastrectomy under laparoscopy. Perioperative indexes such as operative time, intraoperative blood loss, and length of hospital stay were recorded in the two groups. Serum C-reactive protein (CRP) and carcinoembryonic antigen (CEA) levels were analyzed by enzyme-linked immunosorbent assay (ELISA), and the incidence of complications was compared. Based on the clinical analysis of the drug used, the results of association significance were selected, and the top ten results were selected in order of confidence and grouped according to clinical symptoms, respectively, as follows: (1) abdominal distension: Hedyotis diffusa, Radix Pseudostellariae, Poria cocos, Huckleberry, and Coix seed; (2) dry mouth: Poria cocos, Radix Radix Pseudostellariae, Coix seed, Pinellia tuber, and Radix Ophiopogonis. The results showed that the minimum operation time in the observation group was 159.7 ± 13.07 min and the maximum was 172.57 ± 2.47 min, which was lower than that in the control group (the minimum was 172.46 ± 12.45 min and the maximum was 186.49 ± 24.32 min). The length of hospital stay (6.51 ± 1.29 days) was lower than that in the control group (7.56 ± 1.42 days) (P < 0.05). The CEA and CRP levels decreased significantly in both groups after treatment (P < 0.05). However, the observation group's CEA was (4.21 ± 1.05) mg/L and CRP was (8.46 ± 1.25) μg/L. In the control group, CEA was (4.18 ± 1.02) mg/L and CRP was (8.39 ± 1.24) μg/L. There were no significant differences (P < 0.05). The incidence of complications in the observed group was 4.7% lower than 7.0% in the control group (P < 0.05). Therefore, laparoscopic local gastric resection for benign gastric tumors can effectively reduce the incidence of CEA and CRP level and complications and improve the perioperative indicators, which is worth popularizing in clinical practice.Entities:
Mesh:
Year: 2021 PMID: 34567487 PMCID: PMC8457959 DOI: 10.1155/2021/7779693
Source DB: PubMed Journal: J Healthc Eng ISSN: 2040-2295 Impact factor: 2.682
Comparison of perioperative indexes between the two groups.
| Group | The operation time (min) | Intraoperative blood loss (mL) | The length of time (d) |
|---|---|---|---|
| Observation group | 159.4 ± 13.07 | 172.45 ± 24.57 | 6.51 ± 1.29 |
| The control group | 172.46 ± 12.45 | 183.76 ± 24.32 | 7.56 ± 1.42 |
| 4.62 | 2.15 | 3.59 | |
| <0.05 | <0.05 | <0.05 |
Comparison of serological indexes between the two groups.
| Group | CEA (mg/L) | CRP ( | ||
|---|---|---|---|---|
| Before treatment | After treatment | Before treatment | After treatment | |
| Observation group | 13.64 ± 3.25 | 4.21 ± 1.05 | 15.62 ± 1.43 | 8.46 ± 1.25 |
| The control group | 13.62 ± 3.26 | 4.18 ± 1.02 | 15.63 ± 1.44 | 8.39 ± 1.24 |
| 0.03 | 0.13 | 0.03 | 0.26 | |
| >0.05 | >0.05 | >0.05 | >0.05 | |
Figure 1Top 10 drugs in medication frequency.
Drug distribution.
| Sequence | Drug | Usage times | Utilization rate |
|---|---|---|---|
| 1 |
| 229 | 0.7387 |
| 2 |
| 220 | 0.7097 |
| 3 |
| 219 | 0.7065 |
| 4 |
| 210 | 0.6774 |
| 5 |
| 206 | 0.6645 |
| 6 | Raw | 191 | 0.6161 |
| 7 | Method of | 173 | 0.5581 |
| 8 | Main | 172 | 0.5548 |
| 9 |
| 145 | 0.4677 |
| 10 | Notoginseng | 142 | 0.4581 |
| 11 |
| 141 | 0.4548 |
| 12 | Combination | 138 | 0.4452 |
| 13 |
| 134 | 0.4323 |
| 14 |
| 125 | 0.4032 |
| 15 |
| 124 | 0.4000 |
| 16 |
| 120 | 0.3871 |
| 17 |
| 114 | 0.3677 |
| 18 | Having cattail pollen | 107 | 0.3452 |
| 19 | Five fat spirit | 107 | 0.3452 |
| 20 | Fried atractylodes | 105 | 0.3387 |
| 21 | Jade bamboo | 103 | 0.3323 |
| 22 | Hawthorn | 101 | 0.3258 |
| 23 | Purple Perilla leaf | 100 | 0.3226 |
| 24 |
| 97 | 0.3129 |
| 25 |
| 91 | 0.2935 |
| 26 |
| 91 | 0.2935 |
| 27 | Fry radix | 87 | 0.2808 |
| 28 | Plum | 86 | 0.2774 |
| 29 |
| 83 | 0.2677 |
| 30 |
| 75 | 0.2419 |
Figure 2Top 10 frequencies of clinical symptoms.
Distribution of clinical symptoms.
| Sequence | Clinical signs and symptoms | Usage times | Utilization rate |
|---|---|---|---|
| 1 | Dry mouth | 154 | 0.4968 |
| 2 | Abdominal distension | 101 | 0.3258 |
| 3 | Poor appetite | 72 | 0.2323 |
| 4 | Poor sleep soundly | 64 | 0.2065 |
| 5 | Loose stools | 61 | 0.1968 |
| 6 | Fatigue | 60 | 0.1935 |
| 7 | Mouth stick | 57 | 0.1839 |
| 8 | The mouth is bitter | 46 | 0.1484 |
| 9 | Vector frequency gas | 44 | 0.1419 |
| 10 | Courtyard of the new | 39 | 0.1258 |
| 11 | Abdominal pain | 36 | 0.1161 |
| 12 | The acid | 35 | 0.1129 |
| 13 | Belching | 34 | 0.1097 |
| 14 | Bowel | 34 | 0.1097 |
| 15 | Stool hard | 33 | 0.1065 |
| 16 | Limb hemp | 30 | 0.0968 |
| 17 | Then the frequency | 22 | 0.0710 |
| 18 | Since the sweat | 21 | 0.0677 |
| 19 | Nausea | 21 | 0.0677 |
| 20 | Night sweats | 19 | 0.0613 |
| 21 | Then dry | 15 | 0.0484 |
| 22 | Coughing up phlegm | 15 | 0.0484 |
| 23 | Heart palpitations | 15 | 0.0484 |
| 24 | Mucus | 14 | 0.0452 |
| 25 | Lumbar acid | 14 | 0.0452 |
| 26 | Dizzy | 13 | 0.0419 |
| 27 | Limb cold | 13 | 0.0419 |
| 28 | A pain | 12 | 0.0387 |
| 29 | Frequent urination | 10 | 0.0323 |
| 30 | Abdominal | 9 | 0.0290 |
| 31 | Shortness of breath | 9 | 0.0290 |
| 32 | Vomiting | 8 | 0.0258 |
| 33 | Have a stomachache | 8 | 0.0258 |
| 34 | Chest distress | 7 | 0.0226 |
| 35 | The night to urinate | 7 | 0.0226 |
| 36 | More than a dream | 7 | 0.0226 |
Item set of clinical symptoms and association rules outside the drug.
| The sequence | Rules item sets | Support | Degree of confidence |
|---|---|---|---|
| 1 | Abdominal distension- | 0.2557 | 0.7822 |
| 2 | Abdominal distension- | 0.2460 | 0.7525 |
| 3 | Dry mouth- | 0.3657 | 0.7338 |
| 4 | Abdominal distension- | 0.2362 | 0.7228 |
| 5 | Dry mouth- | 0.3560 | 0.7143 |
| 6 | Abdominal distension-Combination | 0.2201 | 0.6733 |
| 7 | Abdominal distension- | 0.2104 | 0.6436 |
| 8 | Dry mouth- | 0.3074 | 0.6169 |
| 9 | Dry mouth-method of | 0.2783 | 0.5584 |
| 10 | Dry mouth-Dwarf | 0.2557 | 0.5130 |
Figure 3Clinical symptoms and confidence of drug association.