INTERPOSITION-ARTHROPLASTY OF THE ELBOW: SYSTEMATIC REVIEW.

OBJECTIVE: To perform a systematic review of the main methods and indications of interposition arthroplasty in the rigid elbow.
METHODS: The research was carried out by three independent researchers, in the databases PubMed, Medline and Embase, according to the descriptors selected as a research strategy and filters selected in the inclusion criteria.
RESULTS: In total, 21 studies were found with the afore mentioned descriptors and which were considered adequate according to the design and relevance according to the type of study and inclusion filters. There was a very strong correlation between the searches of the three researchers (k = 0.809). At the end, 14 complete studies were presented, all of which were included.
CONCLUSION: The main finding of this study was to note that there is an evident lack of research with a high level of real effectiveness and indication for interposition arthroplasty in the rigid elbow. Most studies point to positive results when the patient is young and a total arthroplasty is not indicated. No meta-analysis or randomized clinical trial was found for this specific topic, despite being a technique applied in clinical practice for some decades and showing good results. Level of Evidence V, Systematic Review.

INTRODUÇÃO

The sequelae of severe elbow fractures, arthritis and infections, contribute to varying degrees of stiffness in this joint, and this involvement is commonly called stiff elbow. )-( In the literature, it is described that performing most activities with the upper limbs depends on an elbow range of motion of 100° (Morrey’s functional range), ranging between 30 and 130°, and of 100° of pronation-supination. Loss of these degrees of movement generates functional deficits, preventing simple activities of daily living, such as taking the hand to the mouth and personal hygiene, among others, in addition to progressive and disabling pain. ( ),(

Fractures are largely responsible for this sequel, mostly in young people who practice activities involving great movement of this joint. Elbow arthritis is a debilitating condition that presents with pain, stiffness, and loss of function. The etiology varies and both osteoarthritis and inflammatory arthritis affect the elbow. Primary elbow osteoarthritis is rare and most cases are the result of post-traumatic changes. ( )-(

Rheumatoid arthritis is the most common inflammatory arthritis affecting the elbow. Surgery is indicated when conservative treatment fails. In older, low-demand patients, total elbow replacement provides acceptable first-line therapy. However, the young, high-demand patient poses a challenge because total elbow replacement is not a long-term solution for this group as a result of high rates of relaxation. ( )-(

Surgical treatment for elbow arthritis includes arthroscopic debridement, ulnohumeral arthroplasty, interposition arthroplasty, resection arthroplasty, total elbow arthroplasty, and arthrodesis. The main goal of treatment is to reduce pain and improve function without compromising future surgical options. Arthroplasty is performed for mild to moderate degeneration and can be performed arthroscopically or openly. Satisfactory pain and stiffness relief is achieved in up to 75% of patients, although these results typically deteriorate during the first decade. ( ) Although total elbow arthroplasty is used in patients with osteoarthritis, ( the consensus seems to be that the result is less favorable in younger and more demanding patients. Arthroplasty and resection arthrodesis are not attractive options as a result of a loss of function, and many feel that these procedures should only be used as a last resort.

In this sense, despite being one of the oldest treatment options for elbow arthritis, interposition arthroplasty (IA) seems to be an intermediate solution in this matter. Over the years, various types of interposition have been used, ranging from synthetic grafts to the current preferred option of the Achilles tendon allograft )-( with or without a hinged external fixator as an adjunct It is considered a salvation option in patients where conservative treatment has failed and total elbow arthroplasty is relatively contraindicated9 Due to its importance, this study aimed to carry out a systematic review of the main methods and indications of interposition arthroplasty in stiff elbow.

MATERIALS AND METHODS

Research strategy

Two reviewers independently performed a search with the same descriptors and in the PubMed, Medline and Embase databases, for studies published until December 5, 2017. The following descriptors were used: “Interposition arthroplasty”, “Stiff elbow”, “Functional results”. The following filters were used to reach the expected final result: “Randomized Controlled Trial; “Clinical Trial” “Meta-Analysis” “Systematic Reviews”; “Case Reports”.

Eligibility and Selection Criteria

The studies found were subjected to the following inclusion criteria:

Studies related to the topic;

Studies published in indexed journals;

Articles in languages: English, Spanish and Portuguese;

Studies conducted on humans;

Articles available in full version.

The exclusion criteria were:

Case report studies with incomplete description of the type of graft and follow-up time.

Investigated variables and extracted data

Two independent investigators took part in the search, which followed the same criteria in the selected studies, collecting the following data: Study design, Type of graft, Follow-up time and Study outcome.

RESULTS

Identification of studies and characteristics

According to the search strategy, 21 studies were found with the aforementioned descriptors, which were evaluated for their content according to the study type filters and inclusion criteria. There was a very strong correlation between the searches of the three researchers (k = 0.809). In the end, 14 complete studies remained, all of which were included (Table 1). ( )-(

Table 1

Studies used

Study	Study design	Age group	Follow-up time	Clinical outcome
Burkhart et al.2	Review	Young adult	Not described	Interposition arthroplasty preserves the revision options of reinterposition arthroplasty, as well as the withdrawal of total elbow arthroplasty
Chauhan et al.3	Case series	Average age 57 years old	Average follow-up:3.6 years	An arthroscopically assisted elbow interposition arthroplasty without external hinged fixation can provide satisfactory mid-term results as a rescue procedure for a difficult condition with limited options
Ersen et al.15	Case series	31 years average	87 months	Interposition arthroplasty is a rescue procedure that appears to have good long-term functional results, especially in patients for whom elbow arthroplasty is not suitable. The use of an Achilles allograft for interposition can protect the joint space in the long term.
Sears et al.4	Review	Young and active population	1 year	Patients who report stiffness and pain at the end of movement may benefit from arthroscopic or open osteocapsular debridement. Those with advanced degenerative changes and pain across the range of motion may require joint restoration with interposition arthroplasty
Kokkalis et al.5	Review	Young adults	Not Reported	Arthroscopic or open synovectomy, debridement arthroplasty, and interposition arthroplasty are generally recommended for the young, active patient population.
Miyazaki et al.6	Case series	Average 38 years	54 months	Interposition arthroplasty with fascia lata associated with the use of a dynamic external fixator in stiff elbow is a viable alternative for patients who do not have an indication for total elbow arthroplasty
Nolla et al.7	Case series	Not described	7 years	They obtained good results in elbow extension
Cheung et al.8	Review	Young population	Not described	In young patients with primary osteoarthritis, interposition arthroplasty is a valid option, although arthroscopic debridement has been presented as one of the main advances in these cases today.
Larson and Morrey9	Case series	Young patients	Not described	They observed that the most suitable for interposition arthroplasty were those patients who had post-traumatic elbow arthrosis
Neidel10	Case report	10 years	77 years	Interposition arthroplasty in multifractures of the elbow was a technique chosen due to the patient’s age and presented definitive and positive results.
Mansat11	Review	Not described specific age group	Not Reported	In the surgical treatment of rheumatoid elbow, interposition arthroplasty is a valid option before total arthroplasty, especially in young and severely affected patients
Lee12	Report of 3 cases	Young patients	7.6 years	An increased mean range of motion of 65 degrees was achieved in flexion and extension in two patients and a more functional range in the third. Although this is seen as a rescue procedure in patients who are thought to be too young for elbow arthroplasty, none of the three patients experienced significant pain and none required total elbow arthroplasty after a mean follow-up of 7.6 years
Ljung et al.13	Case series	Young patients	Not described	The authors suggested total elbow arthroplasty as the initial treatment for rheumatoid arthritis
Morrey14	Case series	Not described	94 months	The results of interposition arthroplasty can be gratifying, but the technique is demanding and the complication rate is high.

As a general feature, a total of 72 patients were included in this review, with a mean age of 36.23 ± 15.14 years. Heterogeneity was observed in relation to the study design (Figure 1) and the type of graft used, most of which was derived from Achilles or fascia lata.

Figure 1

Number of articles according to study design.

Furthermore, the result was described as positive in 90% of the articles (Figure 2).

Figure 2

Percentage of articles reporting positive and negative results with the interposition arthroplasty technique.

DISCUSSION

The main finding of this study was to observe that there is an evident lack of research with a high level of reliability for the real efficacy and indication of interposition arthroplasty in stiff elbow. No meta-analysis or randomized clinical trial was found for this specific topic, despite being a technique applied in clinical practice for some decades and with good results.

Elbow arthroplasty is considered the first choice in the treatment of painful elbow arthrosis due to intrinsic factors. However, arthroplasty is not preferred in active young people, especially those who use the elbow in heavy activity. Interposition arthroplasty is one of the preferred treatment options in these patients. (

Several types of allografts are described in the literature, from the Achilles tendon to the fascia lata. ( ),( ),( However, the long-term viability in terms of functional and imaging remains poorly explored. There is uncertainty about the indications and this treatment is rarely applied.

Interposition arthroplasty may be preferred as a salvation procedure for young patients who cannot accept the functional limitations of elbow arthroplasty. ( It is expected that the graft will adapt and the space will disappear over time. Therefore, the goal of this treatment is to gain time with a functional elbow in patients for whom elbow arthroplasty is not suitable.

Cheung et al. ( reported 62% of perfect and good results in 13 patients after distraction interposition arthroplasty with a mean follow-up of 63 months. Four patients required total elbow arthroplasty within 30 months.

Nolla et al. ( reported 13 patients with a mean follow-up of 4 years and found that the flexion-extension range increased from 48° to 110° and 8 patients (62%) had good results. The largest case series on distraction interposition arthroplasty was reported by Larson and Morrey who followed 38 of 69 patients who underwent distraction interposition arthroplasty for 6 years. The authors reported a significant increase in range of motion and functional score. However, 11 (29%) of 38 patients had less satisfactory results and this was associated with greater preoperative stability.

In a study by Erşen et al., ( 5 patients were followed for 87.6 months, with 4 patients with good results and 1 patient with satisfactory results. None of the patients had poor results despite the long follow-up. Besides, none of the patients required total elbow arthroplasty surgery.

Ljung et al. ( only included patients with rheumatoid arthritis in their study and reported that bone destruction due to rheumatoid arthritis made it impossible to apply interposition arthroplasty in these patients. The authors suggested total elbow arthroplasty as the initial treatment for rheumatoid arthritis.

Larson and Morrey observed that the most suitable for interposition arthroplasty were those patients who had post-traumatic arthrosis of the elbow.

Several options for interposition grafts, including the dermis, dura mater, fascia lata, Achilles tendon, and lipid tissue have been reported in the literature. ( ),( ),( ),(

Achilles tendon and fascia lata were the most frequent grafts used in case series by Cheung et al. ( In this study, they included 13 patients in whom only fascia lata autografts were used. In a case series of 38 patients, Larson and Morrey only used Achilles tendon allografts. Although not comparing these two graft options, in previously reported studies, revision rates were 31% with fascia lata and 16% with Achilles tendon.

CONCLUSION

The main finding of this study was to observe that there is an evident lack of research with a high level of reliability for the real efficacy and indication of interposition arthroplasty in stiff elbow. A maioria dos trabalhos aponta para resultados positivos quando o paciente é jovem e a artroplastia total não é indicada. No meta-analysis or randomized clinical trial was found for this specific topic, despite being a technique applied in clinical practice for some decades and with good results.