| Literature DB >> 34565525 |
Carly S Lundgreen1, Dirk R Larson1, Elizabeth J Atkinson1, Katrina L Devick2, David G Lewallen3, Daniel J Berry3, Hilal Maradit Kremers4, Cynthia S Crowson5.
Abstract
Kaplan-Meier survival curves are the most common methods for unadjusted group comparison of outcomes in orthopedic research. However, they may be misleading due to an imbalance of confounders between patient groups. The Cox model is frequently used to adjust for confounders, but graphical display of adjusted survival curves is not commonly utilized. We describe the circumstances when adjusted survival curves are useful in orthopedic research, describe and use 2 different methods to obtain adjusted curves, and illustrate how they can improve understanding of the multivariable Cox model results. We further provide practical strategies for identifying the need for and performing adjusted survival curves. Please visit the followinghttps://youtu.be/ys0hy2CiMCAfor a video that explains the highlights of the paper in practical terms.Entities:
Keywords: Cox model; confounding; survival analysis; survival curves; total joint arthroplasty
Mesh:
Year: 2021 PMID: 34565525 PMCID: PMC8476943 DOI: 10.1016/j.arth.2021.06.002
Source DB: PubMed Journal: J Arthroplasty ISSN: 0883-5403 Impact factor: 4.435