Literature DB >> 34562243

Studying Hedgehog Signaling During Mouse Neural Tube Development.

Sandii Constable1, Kevin White2, Bandarigoda Nipunika Somatilaka2,3, Saikat Mukhopadhyay4.   

Abstract

The identity of ventral neural progenitors in the neural tube is largely dependent on Hedgehog (Hh) signaling. Variations in staining patterns are excellent indicators of aberrant Hh signaling. Here we describe the basic protocol to stain for progenitor populations based on transcription factor expression. We also provide an overview of ciliary and centrosomal staining in the neural tube.
© 2022. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  Centrosome; Cilia; Hedgehog; Immunostaining; Neural tube

Mesh：

Substances：

Year:  2022        PMID： 34562243     DOI： 10.1007/978-1-0716-1701-4_6

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  21 in total

1.  Protein kinase A acts at the basal body of the primary cilium to prevent Gli2 activation and ventralization of the mouse neural tube.

Authors:  Miquel Tuson; Mu He; Kathryn V Anderson
Journal:  Development       Date:  2011-10-17       Impact factor: 6.868

2.  Analysis of hedgehog signaling in mouse intraflagellar transport mutants.

Authors:  Hyuk W Ko; Aimin Liu; Jonathan T Eggenschwiler
Journal:  Methods Cell Biol       Date:  2009-12-04       Impact factor: 1.441

3.  Distinct Sonic Hedgehog signaling dynamics specify floor plate and ventral neuronal progenitors in the vertebrate neural tube.

Authors:  Vanessa Ribes; Nikolaos Balaskas; Noriaki Sasai; Catarina Cruz; Eric Dessaud; Jordi Cayuso; Samuel Tozer; Lin Lin Yang; Ben Novitch; Elisa Marti; James Briscoe
Journal:  Genes Dev       Date:  2010-06-01       Impact factor: 11.361

4.  Altered neural cell fates and medulloblastoma in mouse patched mutants.

Authors:  L V Goodrich; L Milenković; K M Higgins; M P Scott
Journal:  Science       Date:  1997-08-22       Impact factor: 47.728

5.  The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling.

Authors:  Saikat Mukhopadhyay; Xiaohui Wen; Navneet Ratti; Alexander Loktev; Linda Rangell; Suzie J Scales; Peter K Jackson
Journal:  Cell       Date:  2013-01-17       Impact factor: 41.582

6.  Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function.

Authors:  C Chiang; Y Litingtung; E Lee; K E Young; J L Corden; H Westphal; P A Beachy
Journal:  Nature       Date:  1996-10-03       Impact factor: 49.962

7.  Interpretation of the sonic hedgehog morphogen gradient by a temporal adaptation mechanism.

Authors:  Eric Dessaud; Lin Lin Yang; Katy Hill; Barny Cox; Fausto Ulloa; Ana Ribeiro; Anita Mynett; Bennett G Novitch; James Briscoe
Journal:  Nature       Date:  2007-11-29       Impact factor: 49.962

Review 8.  The relationship between sonic Hedgehog signaling, cilia, and neural tube defects.

Authors:  Jennifer N Murdoch; Andrew J Copp
Journal:  Birth Defects Res A Clin Mol Teratol       Date:  2010-08

9.  Ankmy2 Prevents Smoothened-Independent Hyperactivation of the Hedgehog Pathway via Cilia-Regulated Adenylyl Cyclase Signaling.

Authors:  Bandarigoda Nipunika Somatilaka; Sun-Hee Hwang; Vivek Reddy Palicharla; Kevin Andrew White; Hemant Badgandi; John Michael Shelton; Saikat Mukhopadhyay
Journal:  Dev Cell       Date:  2020-07-22       Impact factor: 13.417

10.  The ciliary phosphatidylinositol phosphatase Inpp5e plays positive and negative regulatory roles in Shh signaling.

Authors:  Sandii Constable; Alyssa B Long; Katharine A Floyd; Stéphane Schurmans; Tamara Caspary
Journal:  Development       Date:  2020-02-03       Impact factor: 6.862
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