Chih-Ming Chang1,2,3, Wu-Chia Lo2,3,4, Yi-Ho Young3, Li-Jen Liao2,3,5,6, Po-Hsuan Wu2,7, Ping-Chia Cheng2, Po-Wen Cheng8,9. 1. Department of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan. 2. Department of Otolaryngology, Far Eastern Memorial Hospital, Taipei, Taiwan. 3. Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan. 4. Graduate Institute of Medicine, Yuan Ze University, Taoyuan, Taiwan. 5. Department of Electrical Engineering, Yuan Ze University, Taoyuan, Taiwan. 6. Medical Engineering Office, Far Eastern Memorial Hospital, Taipei, Taiwan. 7. Department of Communication Engineering, Oriental Institute of Technology, Taipei, Taiwan. 8. Department of Otolaryngology, Far Eastern Memorial Hospital, Taipei, Taiwan. powenjapan@yahoo.com.tw. 9. Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan. powenjapan@yahoo.com.tw.
Abstract
PURPOSE: The purpose is to investigate possible vestibulopathy in patients with benign paroxysmal positional vertigo (BPPV), inner ear tests, including cervical and ocular vestibular-evoked myogenic potentials (cVEMPs and oVEMPs) via various stimulation modes, were adopted. METHODS: Fifty BPPV patients were enrolled in this study. All patients underwent pure tone audiometry, cVEMPs, oVEMPs, and caloric tests. The recurrence status, abnormal rates of inner ear tests, and the characteristic parameters of VEMPs, such as wave latencies and amplitudes, were analyzed. RESULTS: In affected ears, the abnormal rates of acoustic cVEMPs, vibratory oVEMPs, galvanic cVEMPs, and galvanic oVEMPs were 62%, 28%, 36%, and 14%, respectively. The abnormalities of acoustic cVEMPs were significantly larger than those of vibratory oVEMPs, and acoustic/vibratory VEMPs had significantly higher abnormal rates than the corresponding galvanic VEMPs. CONCLUSION: BPPV patients may have both otolithic and neural dysfunctions. Otolithic organ damage occurs more frequently than retrootolithic neural degeneration, and the saccular macula might have a greater extent of damage than the utricular macula.
PURPOSE: The purpose is to investigate possible vestibulopathy in patients with benign paroxysmal positional vertigo (BPPV), inner ear tests, including cervical and ocular vestibular-evoked myogenic potentials (cVEMPs and oVEMPs) via various stimulation modes, were adopted. METHODS: Fifty BPPV patients were enrolled in this study. All patients underwent pure tone audiometry, cVEMPs, oVEMPs, and caloric tests. The recurrence status, abnormal rates of inner ear tests, and the characteristic parameters of VEMPs, such as wave latencies and amplitudes, were analyzed. RESULTS: In affected ears, the abnormal rates of acoustic cVEMPs, vibratory oVEMPs, galvanic cVEMPs, and galvanic oVEMPs were 62%, 28%, 36%, and 14%, respectively. The abnormalities of acoustic cVEMPs were significantly larger than those of vibratory oVEMPs, and acoustic/vibratory VEMPs had significantly higher abnormal rates than the corresponding galvanic VEMPs. CONCLUSION: BPPV patients may have both otolithic and neural dysfunctions. Otolithic organ damage occurs more frequently than retrootolithic neural degeneration, and the saccular macula might have a greater extent of damage than the utricular macula.
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