Shashank M Patil1, Prithvi S Shirahatti2, Ramith Ramu1. 1. Department of Biotechnology and Bioinformatics, School of Life Sciences, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India. 2. Department of Biotechnology, Teresian College, Mysuru, Karnataka, India.
Abstract
OBJECTIVE: We aim to provide a critical review focused on the various pharmacological activities of Azadirachta indica A. Juss related to diabetes management. We also emphasise on phytochemistry and toxicology of A. indica, which could provide a comprehensive approach for plant-based drug development in future. KEY FINDINGS: From 2784 identified studies, only 83 were considered after double screening based on the inclusion criteria. Further, 63 pharmacological investigations were considered for review. Resultant studies deliberated on using different extracts and phytochemicals of A. indica on blood glucose level, lipid profile, oxidative stress, carbohydrate digestion enzymes, diabetic complications, glucose tolerance, and uptake of glucose. SUMMARY: In the end, one can know the efficacy of A. indica as a potent antidiabetic herbal medicine. However, based on gaps in research, recommendations have been provided to evaluate A. indica. in a systematic manner to develop plant-based drugs, nutraceuticals, and to evaluate their clinical efficiency and safety against diabetes mellitus.
OBJECTIVE: We aim to provide a critical review focused on the various pharmacological activities of Azadirachta indica A. Juss related to diabetes management. We also emphasise on phytochemistry and toxicology of A. indica, which could provide a comprehensive approach for plant-based drug development in future. KEY FINDINGS: From 2784 identified studies, only 83 were considered after double screening based on the inclusion criteria. Further, 63 pharmacological investigations were considered for review. Resultant studies deliberated on using different extracts and phytochemicals of A. indica on blood glucose level, lipid profile, oxidative stress, carbohydrate digestion enzymes, diabetic complications, glucose tolerance, and uptake of glucose. SUMMARY: In the end, one can know the efficacy of A. indica as a potent antidiabetic herbal medicine. However, based on gaps in research, recommendations have been provided to evaluate A. indica. in a systematic manner to develop plant-based drugs, nutraceuticals, and to evaluate their clinical efficiency and safety against diabetes mellitus.
Authors: Shashank M Patil; Reshma Mary Martiz; A M Satish; Abdullah M Shbeer; Mohammed Ageel; Mohammed Al-Ghorbani; Lakshmi Ranganatha; Saravanan Parameswaran; Ramith Ramu Journal: Molecules Date: 2022-06-17 Impact factor: 4.927
Authors: Reshma Mary Martiz; Shashank M Patil; Deepika Thirumalapura Hombegowda; Abdullah M Shbeer; Taha Alqadi; Mohammed Al-Ghorbani; Ramith Ramu; Ashwini Prasad Journal: Molecules Date: 2022-09-22 Impact factor: 4.927