Literature DB >> 3456176

Assignment of human 3-hydroxy-3-methylglutaryl coenzyme A reductase gene to q13----q23 region of chromosome 5.

T Mohandas, C Heinzmann, R S Sparkes, J Wasmuth, P Edwards, A J Lusis.   

Abstract

We have used hamster cDNA probes for 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase (HMGCR) to determine the chromosomal location of the human gene for HMG CoA reductase. Southern blot analysis of genomic DNA from 16 independent mouse-human somatic cell hybrids showed that the human gene for HMG CoA reductase resides on chromosome 5. Analysis of Chinese hamster-human somatic cell hybrids selectively retaining human 5 or a portion of it showed that the gene locus for HMG CoA reductase can be assigned to the q13----q23 region of chromosome 5.

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Year:  1986        PMID： 3456176     DOI： 10.1007/BF01560731

Source DB:  PubMed          Journal:  Somat Cell Mol Genet        ISSN： 0740-7750


  18 in total

Review 1.  Comparative map for mice and humans.

Authors:  J H Nadeau; M T Davisson; D P Doolittle; P Grant; A L Hillyard; M R Kosowsky; T H Roderick
Journal:  Mamm Genome       Date:  1992       Impact factor: 2.957

2.  Cloning and chromosomal mapping of a human immunodeficiency virus 1 "TATA" element modulatory factor.

Authors:  J A Garcia; S H Ou; F Wu; A J Lusis; R S Sparkes; R B Gaynor
Journal:  Proc Natl Acad Sci U S A       Date:  1992-10-15       Impact factor: 11.205

3.  Linkage analysis of Norrie disease with X-chromosomal ornithine aminotransferase.

Authors:  J B Bateman
Journal:  Trans Am Ophthalmol Soc       Date:  1992

4.  Regional assignment of the human uroporphyrinogen III synthase (UROS) gene to chromosome 10q25.2----q26.3.

Authors:  K H Astrin; C A Warner; H W Yoo; P J Goodfellow; S F Tsai; R J Desnick
Journal:  Hum Genet       Date:  1991-05       Impact factor: 4.132

Review 5.  Comparative map for mice and humans.

Authors:  J H Nadeau; M T Davisson; D P Doolittle; P Grant; A L Hillyard; M Kosowsky; T H Roderick
Journal:  Mamm Genome       Date:  1991       Impact factor: 2.957

6.  A human D1 dopamine receptor gene is located on chromosome 5 at q35.1 and identifies an EcoRI RFLP.

Authors:  D K Grandy; Q Y Zhou; L Allen; R Litt; R E Magenis; O Civelli; M Litt
Journal:  Am J Hum Genet       Date:  1990-11       Impact factor: 11.025

7.  Human ferritin genes: chromosomal assignments and polymorphisms.

Authors:  R A Gatti; R Shaked; T K Mohandas; W Salser
Journal:  Am J Hum Genet       Date:  1987-10       Impact factor: 11.025

8.  The genes coding for human pro alpha 1(IV) collagen and pro alpha 2(IV) collagen are both located at the end of the long arm of chromosome 13.

Authors:  C D Boyd; S E Toth-Fejel; I K Gadi; M Litt; M R Condon; M Kolbe; I K Hagen; M Kurkinen; J W Mackenzie; E Magenis
Journal:  Am J Hum Genet       Date:  1988-02       Impact factor: 11.025

9.  Cloning and chromosomal localization of a human kidney cDNA involved in cystine, dibasic, and neutral amino acid transport.

Authors:  W S Lee; R G Wells; R V Sabbag; T K Mohandas; M A Hediger
Journal:  J Clin Invest       Date:  1993-05       Impact factor: 14.808

10.  Cytogenetic and molecular studies on a recombinant human X chromosome: implications for the spreading of X chromosome inactivation.

Authors:  T Mohandas; R L Geller; P H Yen; J Rosendorff; R Bernstein; A Yoshida; L J Shapiro
Journal:  Proc Natl Acad Sci U S A       Date:  1987-07       Impact factor: 11.205
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