Literature DB >> 34554889

Erwin Knecht-the intelligent and mad, funny and grumpy man of autophagy.

Erwin Knecht1, Daniel J Klionsky2.   

Abstract

Getting to know Erwin Knecht is not so simple. This view was summarized in a comment from Dr. Marta Martinez Vicente, who obtained her PhD degree working in a lab that shared space with Erwin's group: "Erwin Knecht is a complex character, who awakens contradictory feelings. To define him I would say that he is a mixture of intelligence and madness, he's witty, very funny but also grumpy and cranky, all mixed and all simultaneously. Without a doubt he is a person who will not leave anyone indifferent, his original personality marked all who crossed his path, doctoral students, collaborators, people who attended his talks, etc … I remember the weekly lab meetings with him; we, the students, had a lot of respect for him (not to mention fear), but his comments were always smart, helpful and constructive, he has always been prone to helping everyone. In the lab, he was extremely demanding, but got people under his supervision to do their best. And despite his usual moodiness, he managed to make everyone love him and have a special affection for him. Above all, I remember his screams throughout the laboratory that could be heard from all over the building, calling out to his laboratory technician: 'Asunción!' They were like an old couple, arguing all day but they couldn't be without each other, it was like watching a sitcom every day." If you are intrigued, please read on.

Entities:  

Keywords:  Biography; chaperone-mediated autophagy; drama; lysosome; proteasome; protein turnover

Mesh:

Year:  2021        PMID: 34554889      PMCID: PMC9037411          DOI: 10.1080/15548627.2021.1962206

Source DB:  PubMed          Journal:  Autophagy        ISSN: 1554-8627            Impact factor:   13.391


  18 in total

1.  Use of inductively coupled plasma-mass spectrometry for the quantitation of the binding and uptake of colloidal gold-low-density lipoprotein conjugates by cultured cells.

Authors:  J J Martin de Llano; E J Andreu; E Knecht
Journal:  Anal Biochem       Date:  1996-12-15       Impact factor: 3.365

2.  Oxidative stress regulates the ubiquitin-proteasome system and immunoproteasome functioning in a mouse model of X-adrenoleukodystrophy.

Authors:  Nathalie Launay; Montserrat Ruiz; Stéphane Fourcade; Agatha Schlüter; Cristina Guilera; Isidre Ferrer; Erwin Knecht; Aurora Pujol
Journal:  Brain       Date:  2013-03       Impact factor: 13.501

3.  Impaired autophagy in Lafora disease.

Authors:  Erwin Knecht; Carmen Aguado; Sovan Sarkar; Viktor I Korolchuk; Olga Criado-García; Santiago Vernia; Patricia Boya; Pascual Sanz; Santiago Rodríguez de Córdoba; David C Rubinsztein
Journal:  Autophagy       Date:  2010-10-11       Impact factor: 16.016

Review 4.  Intracellular protein degradation in mammalian and bacterial cells: Part 2.

Authors:  A L Goldberg; A C St John
Journal:  Annu Rev Biochem       Date:  1976       Impact factor: 23.643

5.  Ultastructural localization of polysaccharides in the vacuolar system of an established cell line.

Authors:  E Knecht; J Hernández
Journal:  Cell Tissue Res       Date:  1978-10-30       Impact factor: 5.249

6.  Import of a cytosolic protein into lysosomes by chaperone-mediated autophagy depends on its folding state.

Authors:  N Salvador; C Aguado; M Horst; E Knecht
Journal:  J Biol Chem       Date:  2000-09-01       Impact factor: 5.157

7.  Uptake and degradation of glyceraldehyde-3-phosphate dehydrogenase by rat liver lysosomes.

Authors:  F Aniento; E Roche; A M Cuervo; E Knecht
Journal:  J Biol Chem       Date:  1993-05-15       Impact factor: 5.157

8.  Laforin, the most common protein mutated in Lafora disease, regulates autophagy.

Authors:  Carmen Aguado; Sovan Sarkar; Viktor I Korolchuk; Olga Criado; Santiago Vernia; Patricia Boya; Pascual Sanz; Santiago Rodríguez de Córdoba; Erwin Knecht; David C Rubinsztein
Journal:  Hum Mol Genet       Date:  2010-05-07       Impact factor: 6.150

9.  Degradation of proteasomes by lysosomes in rat liver.

Authors:  A M Cuervo; A Palmer; A J Rivett; E Knecht
Journal:  Eur J Biochem       Date:  1995-02-01

10.  Involvement of mitochondrial dynamics in the segregation of mitochondrial matrix proteins during stationary phase mitophagy.

Authors:  Hagai Abeliovich; Mostafa Zarei; Kristoffer T G Rigbolt; Richard J Youle; Joern Dengjel
Journal:  Nat Commun       Date:  2013       Impact factor: 14.919

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