Literature DB >> 34553301

MRI-Based Markers of Changes in the Supragranular Cortical Layer in Individuals at Clinically High Risk of Endogenous Psychosis.

A S Tomyshev1, I S Lebedeva2, M A Omelchenko2, V G Kaleda2.   

Abstract

We analyzed morphometric MRI parameters indirectly attesting to structural changes in the supragranular layer in 33 non-converted individuals at clinical high risk for endogenous psychosis (follow-up period of 6.7±0.6 years) and in 34 sex- and age-matched healthy controls. In the group of clinical high-risk individuals, changes indicative of potential predominance of supragranular thinning in comparison with a decrease of infragranular cortical layer thickness were revealed. The results are discussed in the context of the concepts of resilience and risk markers of developing endogenous psychosis.
© 2021. Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  MRI; clinical high risk; endogenous psychosis; supragranular layer; surfacebased morphometry

Mesh：

Substances：

Year:  2021        PMID： 34553301     DOI： 10.1007/s10517-021-05256-7

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


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