Richard Goodall1,2, Justin D Salciccioli3, Alun Huw Davies1,2, Dominic Marshall4, Joseph Shalhoub1,2. 1. Academic Section of Vascular Surgery, Department of Surgery and Cancer, Imperial College London, UK. 2. Department of Vascular Surgery, Imperial College Healthcare NHS Trust, London, UK. 3. Department of Medicine, Mount Auburn Hospital, Harvard Medical School, Cambridge, MA, USA. 4. Critical Care Research Group, Nuffield Department of Clinical Neurosciences, University of Oxford, UK.
Abstract
AIMS: The aim was to assess trends in peripheral arterial disease (PAD) incidence and mortality rates in European Union(15+) countries between 1990 and 2017. METHODS AND RESULTS: This observational study used data obtained from the 2017 Global Burden of Disease study. Age-standardised mortality and incidence rates from PAD were extracted from the Global Health Data Exchange for EU15+ countries for the years 1990-2017. Trends were analysed using Joinpoint regression analysis.Between 1990 and 2017, the incidence of PAD decreased in all 19 EU15+ countries for females, and in 18 of 19 countries for males. Increasing PAD incidence was observed only for males in the United States (+1.4%). In 2017, the highest incidence rates were observed in Denmark and the United States for males (213.6 and 202.3 per 100,000, respectively) and in the United States and Canada for females (194.8 and 171.1 per 100,000, respectively). There was a concomitant overall trend for increasing age-standardised mortality rates in all EU15+ countries for females, and in 16 of 19 EU15+ countries for males between 1990 and 2017. Italy (-25.1%), Portugal (-1.9%) and Sweden (-0.6%) were the only countries with reducing PAD mortality rates in males. The largest increases in mortality rates were observed in the United Kingdom (males +140.4%, females +158.0%) and the United States (males +125.7%, females +131.2%). CONCLUSIONS: We identify shifting burden of PAD in EU15+ countries, with increasing mortality rates despite reducing incidence. Strong evidence supports goal-directed medical therapy in reducing PAD mortality - population-wide strategies to improve compliance to optimal goal-directed medical therapy are warranted. Published on behalf of the European Society of Cardiology. All rights reserved.
AIMS: The aim was to assess trends in peripheral arterial disease (PAD) incidence and mortality rates in European Union(15+) countries between 1990 and 2017. METHODS AND RESULTS: This observational study used data obtained from the 2017 Global Burden of Disease study. Age-standardised mortality and incidence rates from PAD were extracted from the Global Health Data Exchange for EU15+ countries for the years 1990-2017. Trends were analysed using Joinpoint regression analysis.Between 1990 and 2017, the incidence of PAD decreased in all 19 EU15+ countries for females, and in 18 of 19 countries for males. Increasing PAD incidence was observed only for males in the United States (+1.4%). In 2017, the highest incidence rates were observed in Denmark and the United States for males (213.6 and 202.3 per 100,000, respectively) and in the United States and Canada for females (194.8 and 171.1 per 100,000, respectively). There was a concomitant overall trend for increasing age-standardised mortality rates in all EU15+ countries for females, and in 16 of 19 EU15+ countries for males between 1990 and 2017. Italy (-25.1%), Portugal (-1.9%) and Sweden (-0.6%) were the only countries with reducing PAD mortality rates in males. The largest increases in mortality rates were observed in the United Kingdom (males +140.4%, females +158.0%) and the United States (males +125.7%, females +131.2%). CONCLUSIONS: We identify shifting burden of PAD in EU15+ countries, with increasing mortality rates despite reducing incidence. Strong evidence supports goal-directed medical therapy in reducing PAD mortality - population-wide strategies to improve compliance to optimal goal-directed medical therapy are warranted. Published on behalf of the European Society of Cardiology. All rights reserved.
Authors: James Schuster-Bruce; Chinmay Jani; Richard Goodall; Dae Kim; William Hughes; Justin D Salciccioli; Dominic Marshall; Joseph Shalhoub Journal: JAMA Otolaryngol Head Neck Surg Date: 2022-04-01 Impact factor: 8.961
Authors: Richard Goodall; Alexander Armstrong; William Hughes; Charles A Fries; Dominic Marshall; Eleanor B Harbinson; Justin Salciccioli; Joseph Shalhoub Journal: Plast Reconstr Surg Glob Open Date: 2020-11-23
Authors: Dominic C Marshall; Omar Al Omari; Richard Goodall; Joseph Shalhoub; Ian M Adcock; Kian Fan Chung; Justin D Salciccioli Journal: BMC Pulm Med Date: 2022-07-28 Impact factor: 3.320
Authors: Justin D Salciccioli; Dominic C Marshall; Richard Goodall; Conor Crowley; Joseph Shalhoub; Preya Patel; Philip L Molyneaux Journal: ERJ Open Res Date: 2022-07-11
Authors: Richard Goodall; Andrew Alazawi; Will Hughes; Vassiliki Bravis; Justin D Salciccioli; Dominic C Marshall; Conor Crowley; Joseph Shalhoub Journal: Sci Rep Date: 2021-07-28 Impact factor: 4.996