Emmanouela Sdona1, Sandra Ekström1,2, Niklas Andersson1, Jenny Hallberg3,4, Susanne Rautiainen5,6,7, Niclas Håkansson1, Alicja Wolk1,8, Inger Kull3,4, Erik Melén1,3,4, Anna Bergström1,2. 1. Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. 2. Centre for Occupational and Environmental Medicine, Stockholm, Sweden. 3. Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden. 4. Sachs' Children and Youth Hospital, Södersjukhuset, Stockholm, Sweden. 5. Global and Sexual Health, Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden. 6. Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA. 7. Astrid Lindgrens Children's Hospital, Karolinska University Hospital, Stockholm, Sweden. 8. Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Abstract
BACKGROUND: Dietary antioxidants may protect the lung against oxidative damage and prevent chronic respiratory disease. We aimed to investigate fruit, vegetable and antioxidant intake (measured as total antioxidant capacity, TAC) at age 8 years in relation to asthma and lung function up to 24 years. METHODS: In this study of 2506 participants from a Swedish birth cohort, diet was assessed using food frequency questionnaires. Information on asthma was collected by questionnaires, and lung function was measured by spirometry at ages 8, 16 and 24 years. Generalized estimating equations and mixed effect models were used to assess overall, age- and sex-specific associations. RESULTS: After adjustment for confounders, a higher fruit intake at age 8 years was associated with a tendency to reduced odds of prevalent asthma (T3 vs. T1, OR 0.78; 95% CI 0.60-1.01, p-trend .083), with reduced odds of incident asthma and increased odds of remittent asthma (≥median, OR 0.76; 95% CI 0.58-0.99 and OR 1.60; 95% CI 1.05-2.42, respectively) up to 24 years. Comparable, but non-significant, odds ratios were observed in analyses of long-term fruit intake (mean intake at ages 8 and 16 years). In contrast, no association was observed with vegetable intake. A higher dietary TAC (T3 vs. T1) at 8 years was associated with reduced odds of prevalent asthma (OR 0.73; 95% CI 0.58-0.93, p-trend .010) and improved lung function development (FEV1 -z +0.11; 95% CI 0.01-0.21, p-trend .036 and FVC-z +0.09; 95% CI -0.01-0.20, p-trend .072) up to 24 years. Associations were more pronounced among males, and regarding asthma, participants sensitized to aeroallergens. CONCLUSIONS: Antioxidant intake in school age may improve asthma and lung function up to young adulthood. Although our results should be interpreted with caution, they emphasize the importance of following current dietary guidelines regarding consumption of antioxidant-rich foods as part of a balanced diet.
BACKGROUND: Dietary antioxidants may protect the lung against oxidative damage and prevent chronic respiratory disease. We aimed to investigate fruit, vegetable and antioxidant intake (measured as total antioxidant capacity, TAC) at age 8 years in relation to asthma and lung function up to 24 years. METHODS: In this study of 2506 participants from a Swedish birth cohort, diet was assessed using food frequency questionnaires. Information on asthma was collected by questionnaires, and lung function was measured by spirometry at ages 8, 16 and 24 years. Generalized estimating equations and mixed effect models were used to assess overall, age- and sex-specific associations. RESULTS: After adjustment for confounders, a higher fruit intake at age 8 years was associated with a tendency to reduced odds of prevalent asthma (T3 vs. T1, OR 0.78; 95% CI 0.60-1.01, p-trend .083), with reduced odds of incident asthma and increased odds of remittent asthma (≥median, OR 0.76; 95% CI 0.58-0.99 and OR 1.60; 95% CI 1.05-2.42, respectively) up to 24 years. Comparable, but non-significant, odds ratios were observed in analyses of long-term fruit intake (mean intake at ages 8 and 16 years). In contrast, no association was observed with vegetable intake. A higher dietary TAC (T3 vs. T1) at 8 years was associated with reduced odds of prevalent asthma (OR 0.73; 95% CI 0.58-0.93, p-trend .010) and improved lung function development (FEV1 -z +0.11; 95% CI 0.01-0.21, p-trend .036 and FVC-z +0.09; 95% CI -0.01-0.20, p-trend .072) up to 24 years. Associations were more pronounced among males, and regarding asthma, participants sensitized to aeroallergens. CONCLUSIONS: Antioxidant intake in school age may improve asthma and lung function up to young adulthood. Although our results should be interpreted with caution, they emphasize the importance of following current dietary guidelines regarding consumption of antioxidant-rich foods as part of a balanced diet.
Authors: George Antonogeorgos; Demosthenes B Panagiotakos; Kostas N Priftis; Evangelia Liakou; Alexandra Koutsokera; Pavlos Drakontaeidis; Marina Thanasia; Maria Mandrapylia; Dafni Moriki; Philippa Ellwood; Luis García-Marcos; Konstantinos Douros Journal: Children (Basel) Date: 2022-05-09
Authors: Katharina C Wirnitzer; Clemens Drenowatz; Armando Cocca; Derrick R Tanous; Mohamad Motevalli; Gerold Wirnitzer; Manuel Schätzer; Gerhard Ruedl; Werner Kirschner Journal: Int J Environ Res Public Health Date: 2021-12-03 Impact factor: 3.390
Authors: Katharina C Wirnitzer; Derrick R Tanous; Mohamad Motevalli; Georg Göbel; Gerold Wirnitzer; Clemens Drenowatz; Gerhard Ruedl; Armando Cocca; Werner Kirschner Journal: Front Sports Act Living Date: 2022-09-28