Performance of deep convolutional neural network for classification and detection of oral potentially malignant disorders in photographic images.

Oral potentially malignant disorders (OPMDs) are a group of conditions that can transform into oral cancer. The purpose of this study was to evaluate convolutional neural network (CNN) algorithms to classify and detect OPMDs in oral photographs. In this study, 600 oral photograph images were collected retrospectively and grouped into 300 images of OPMDs and 300 images of normal oral mucosa. CNN-based classification models were created using DenseNet-121 and ResNet-50. The detection models were created using Faster R-CNN and YOLOv4. The image data were randomly selected and assigned as training, validating, and testing data. The testing data were evaluated to compare the performance of the CNN models with the diagnosis results produced by oral and maxillofacial surgeons. DenseNet-121 and ResNet-50 were found to produce high efficiency in diagnosis of OPMDs, with an area under the receiver operating characteristic curve (AUC) of 95%. Faster R-CNN yielded the highest detection performance, with an AUC of 74.34%. For the CNN-based classification model, the sensitivity and specificity were 100% and 90%, respectively. For the oral and maxillofacial surgeons, these values were 91.73% and 92.27%, respectively. In conclusion, the DenseNet-121, ResNet-50 and Faster R-CNN models have potential for the classification and detection of OPMDs in oral photographs.