Christopher E Niemczak1, Travis White-Schwoch2, Abigail Fellows1, Albert Magohe3, Jiang Gui4, Catherine Rieke1, Trent Nicol2, Enica R Massawe3, Ndeserua Moshi3, Nina Kraus2,5, Jay C Buckey1. 1. Space Medicine Innovations Lab, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA. 2. Auditory Neuroscience Laboratory, Department of Communication Sciences, Northwestern University, Evanston, Illinois, USA. 3. Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania. 4. Department of Data Science, Dartmouth College, Hanover, New Hampshire, USA. 5. Departments of Neurobiology and Otolaryngology, Northwestern University, Evanston, Illinois, USA.
Abstract
OBJECTIVE: Little is known about peripheral auditory function in young adults with HIV, who might be expected to show early evidence of hearing loss if HIV infection or treatment does affect peripheral function. The goal of this study was to compare peripheral auditory function in 2 age- and gender-matched groups of young adults with clinically normal hearing with and without HIV. STUDY DESIGN: Matched cohort study with repeated measures. SETTING: Infectious disease center in Dar es Salaam, Tanzania. METHODS: Participants included HIV-positive (n = 38) and HIV-negative (n = 38) adults aged 20 to 30 years who had clinically normal hearing, defined as type A tympanograms, air conduction thresholds ≤25 dB HL bilaterally from 0.5 to 8 kHz, and distortion product otoacoustic emissions (DPOAEs) >6 dB above the noise floor bilaterally from 1.5 to 8 kHz. Participants were tested multiple times over 6-month intervals (average, 2.7 sessions/participant) for a total of 208 observations. Primary outcome measures included tympanograms, air conduction audiograms, DPOAEs, and click-evoked auditory brainstem responses. RESULTS: HIV groups did not significantly differ in age, static immittance, or air conduction thresholds. HIV-positive status was independently associated with approximately 3.7-dB lower DPOAE amplitudes from 2 to 8 kHz (95% CI, 1.01-6.82) in both ears and 0.04-µV lower (95% CI, 0.003-0.076) auditory brainstem response wave I amplitudes in the right ear. CONCLUSION: Young adults living with HIV have slightly but reliably smaller DPOAEs and auditory brainstem response wave I amplitudes than matched HIV-negative controls. The magnitude of these differences is small, but these results support measuring peripheral auditory function in HIV-positive individuals as they age.
OBJECTIVE: Little is known about peripheral auditory function in young adults with HIV, who might be expected to show early evidence of hearing loss if HIV infection or treatment does affect peripheral function. The goal of this study was to compare peripheral auditory function in 2 age- and gender-matched groups of young adults with clinically normal hearing with and without HIV. STUDY DESIGN: Matched cohort study with repeated measures. SETTING: Infectious disease center in Dar es Salaam, Tanzania. METHODS: Participants included HIV-positive (n = 38) and HIV-negative (n = 38) adults aged 20 to 30 years who had clinically normal hearing, defined as type A tympanograms, air conduction thresholds ≤25 dB HL bilaterally from 0.5 to 8 kHz, and distortion product otoacoustic emissions (DPOAEs) >6 dB above the noise floor bilaterally from 1.5 to 8 kHz. Participants were tested multiple times over 6-month intervals (average, 2.7 sessions/participant) for a total of 208 observations. Primary outcome measures included tympanograms, air conduction audiograms, DPOAEs, and click-evoked auditory brainstem responses. RESULTS: HIV groups did not significantly differ in age, static immittance, or air conduction thresholds. HIV-positive status was independently associated with approximately 3.7-dB lower DPOAE amplitudes from 2 to 8 kHz (95% CI, 1.01-6.82) in both ears and 0.04-µV lower (95% CI, 0.003-0.076) auditory brainstem response wave I amplitudes in the right ear. CONCLUSION: Young adults living with HIV have slightly but reliably smaller DPOAEs and auditory brainstem response wave I amplitudes than matched HIV-negative controls. The magnitude of these differences is small, but these results support measuring peripheral auditory function in HIV-positive individuals as they age.
Authors: Jay C Buckey; Abigail M Fellows; Albert Magohe; Isaac Maro; Jiang Gui; Odile Clavier; Enica Massawe; Ndeserua Moshi Journal: AIDS Date: 2019-07-15 Impact factor: 4.177
Authors: Isaac I Maro; Ndeserua Moshi; Odile H Clavier; Todd A MacKenzie; Robert J Kline-Schoder; Jed C Wilbur; Robert D Chambers; Abigail M Fellows; Benjamin G Jastrzembski; John E Mascari; Muhammad Bakari; Mecky Matee; Frank E Musiek; Richard D Waddell; C Fordham von Reyn; Jay C Buckey Journal: Ear Hear Date: 2014 May-Jun Impact factor: 3.570
Authors: Peter Torre; Howard J Hoffman; Gayle Springer; Christopher Cox; Mary Young; Joseph B Margolick; Michael Plankey Journal: Ear Hear Date: 2014 Jan-Feb Impact factor: 3.570
Authors: Travis White-Schwoch; Albert K Magohe; Abigail M Fellows; Catherine C Rieke; Brandon Vilarello; Trent Nicol; Enica R Massawe; Ndeserua Moshi; Nina Kraus; Jay C Buckey Journal: Clin Neurophysiol Date: 2020-05-22 Impact factor: 3.708