Eliano P Navarese1,2,3, Felicita Andreotti4,5. 1. Interventional Cardiology and Cardiovascular Medicine Research, Department of Cardiology and Internal Medicine, Nicolaus Copernicus University, M. Skłodowskiej-Curie Street No 9, Bydgoszcz 85-094, Poland. 2. Faculty of Medicine, Department of Cardiology, 11220 83rd Avenue NW, Edmonton, AB T6G 2B7, Canada. 3. SIRIO MEDICINE Research Network, M. Skłodowskiej-Curie Street No 9, Bydgoszcz 85-094, Poland. 4. Dept of Cardiovascular Science, Fondazione Policlinico Universitario Gemelli IRCCS, Largo F. Vito 1, Rome 00168, Italy. 5. Catholic University Medical School, Largo F Vito 1, Rome 00168, Italy.