Literature DB >> 34543090

The QcrB Inhibitors TB47 and Telacebec Do Not Potentiate the Activity of Clofazimine in Mycobacterium abscessus.

Ria Sorayah1,2, Garret C Moraski3, Daniel Barkan4, Kevin Pethe2,5.   

Abstract

The antituberculosis drug telacebec is ineffective against Mycobacterium abscessus. A recent study suggested that TB47, a telacebec analogue, potentiated the efficacy of clofazimine against M. abscessus. Here, we report that TB47 not only is ineffective against M. abscessus in vitro but also does not potentiate the activity of clofazimine.

Entities:  

Keywords:  Q203; cytochrome bcc:aa3; nontuberculous mycobacteria; oxidative phosphorylation; terminal oxidase; tuberculosis

Mesh：

Substances：

Year:  2021        PMID： 34543090      PMCID： PMC8597762          DOI： 10.1128/AAC.00964-21

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  13 in total

1.  Bedaquiline Inhibits the ATP Synthase in Mycobacterium abscessus and Is Effective in Infected Zebrafish.

Authors:  Christian Dupont; Albertus Viljoen; Sangeeta Thomas; Françoise Roquet-Banères; Jean-Louis Herrmann; Kevin Pethe; Laurent Kremer
Journal:  Antimicrob Agents Chemother       Date:  2017-10-24       Impact factor: 5.191

2.  Assessment of Clofazimine and TB47 Combination Activity against Mycobacterium abscessus Using a Bioluminescent Approach.

Authors:  Yang Liu; Yaoju Tan; M Mahmudul Islam; Yuanyuan Cao; Xiaoyun Lu; Sheng Zeng; H M Adnan Hameed; Peipei Zhou; Xingshan Cai; Shuai Wang; Julius N Mugweru; Guoliang Zhang; Huancai Yin; Jianxiong Liu; Eric Nuermberger; Tianyu Zhang
Journal:  Antimicrob Agents Chemother       Date:  2020-02-21       Impact factor: 5.191

3.  Establishment and Validation of Galleria mellonella as a Novel Model Organism To Study Mycobacterium abscessus Infection, Pathogenesis, and Treatment.

Authors:  Michal Meir; Tatyana Grosfeld; Daniel Barkan
Journal:  Antimicrob Agents Chemother       Date:  2018-03-27       Impact factor: 5.191

Review 4.  Mycobacterium abscessus: a new antibiotic nightmare.

Authors:  Rachid Nessar; Emmanuelle Cambau; Jean Marc Reyrat; Alan Murray; Brigitte Gicquel
Journal:  J Antimicrob Chemother       Date:  2012-01-30       Impact factor: 5.790

5.  Exploiting the synthetic lethality between terminal respiratory oxidases to kill Mycobacterium tuberculosis and clear host infection.

Authors:  Nitin P Kalia; Erik J Hasenoehrl; Nurlilah B Ab Rahman; Vanessa H Koh; Michelle L T Ang; Dannah R Sajorda; Kiel Hards; Gerhard Grüber; Sylvie Alonso; Gregory M Cook; Michael Berney; Kevin Pethe
Journal:  Proc Natl Acad Sci U S A       Date:  2017-06-26       Impact factor: 11.205

Review 6.  Pulmonary disease caused by rapidly growing mycobacteria.

Authors:  Charles L Daley; David E Griffith
Journal:  Clin Chest Med       Date:  2002-09       Impact factor: 2.878

7.  Naturally-Occurring Polymorphisms in QcrB Are Responsible for Resistance to Telacebec in Mycobacterium abscessus.

Authors:  Ria Sorayah; Malathy Sony Subramanian Manimekalai; Sung Jae Shin; Won-Jung Koh; Gerhard Grüber; Kevin Pethe
Journal:  ACS Infect Dis       Date:  2019-10-14       Impact factor: 5.084

8.  Optimisation of bioluminescent reporters for use with mycobacteria.

Authors:  Nuria Andreu; Andrea Zelmer; Taryn Fletcher; Paul T Elkington; Theresa H Ward; Jorge Ripoll; Tanya Parish; Gregory J Bancroft; Ulrich Schaible; Brian D Robertson; Siouxsie Wiles
Journal:  PLoS One       Date:  2010-05-24       Impact factor: 3.240

9.  Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis.

Authors:  Kevin Pethe; Pablo Bifani; Jichan Jang; Sunhee Kang; Seijin Park; Sujin Ahn; Jan Jiricek; Juyoung Jung; Hee Kyoung Jeon; Jonathan Cechetto; Thierry Christophe; Honggun Lee; Marie Kempf; Mary Jackson; Anne J Lenaerts; Ha Pham; Victoria Jones; Min Jung Seo; Young Mi Kim; Mooyoung Seo; Jeong Jea Seo; Dongsik Park; Yoonae Ko; Inhee Choi; Ryangyeo Kim; Se Yeon Kim; SeungBin Lim; Seung-Ae Yim; Jiyoun Nam; Hwankyu Kang; Haejin Kwon; Chun-Taek Oh; Yoojin Cho; Yunhee Jang; Junghwan Kim; Adeline Chua; Bee Huat Tan; Mahesh B Nanjundappa; Srinivasa P S Rao; Whitney S Barnes; René Wintjens; John R Walker; Sylvie Alonso; Saeyeon Lee; Jungjun Kim; Soohyun Oh; Taegwon Oh; Ulf Nehrbass; Sung-Jun Han; Zaesung No; Jinhwa Lee; Priscille Brodin; Sang-Nae Cho; Kiyean Nam; Jaeseung Kim
Journal:  Nat Med       Date:  2013-08-04       Impact factor: 53.440

10.  Clinical and microbiological characteristics of non-tuberculous mycobacteria diseases in Singapore with a focus on pulmonary disease, 2012-2016.

Authors:  Zoe Xiaozhu Zhang; Benjamin Pei Zhi Cherng; Li-Hwei Sng; Yen Ee Tan
Journal:  BMC Infect Dis       Date:  2019-05-17       Impact factor: 3.090
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