Literature DB >> 34542757

Efficacy of BCG Vaccination Depends on Host Genetics.

B V Nikonenko1, N N Logunova2, N V Sterzhanova2, S I Kayukova2, A S Apt2.   

Abstract

We studied the effectiveness of anti-tuberculosis vaccination with BCG in mice of inbred strains and F1 hybrids (highly resistant to tuberculosis infection) that represent a wide range of genetically determined differences in susceptibility to infection with virulent Mycobacterium tuberculosis. The greatest relative effect was found in susceptible mice, with the exception of highly susceptible I/St mice that were practically not protected by vaccination. Despite significant effect of vaccination in inbred mice, their resistance to M. tuberculosis infection did not exceed that of non-vaccinated highly resistant F1 hybrids.
© 2021. Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  BCG; M. tuberculosis; inbred mice; mean survival rate; vaccination

Mesh：

Substances：

Year:  2021        PMID： 34542757     DOI： 10.1007/s10517-021-05246-9

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  11 in total

Review 1.  Prospects in Mycobacterium bovis Bacille Calmette et Guérin (BCG) vaccine diversity and delivery: why does BCG fail to protect against tuberculosis?

Authors:  Juan I Moliva; Joanne Turner; Jordi B Torrelles
Journal:  Vaccine       Date:  2015-08-28       Impact factor: 3.641

2.  B cells delay neutrophil migration toward the site of stimulus: tardiness critical for effective bacillus Calmette-Guérin vaccination against tuberculosis infection in mice.

Authors:  Tatiana K Kondratieva; Elvira I Rubakova; Irina A Linge; Vladimir V Evstifeev; Konstantin B Majorov; Alexander S Apt
Journal:  J Immunol       Date:  2009-12-18       Impact factor: 5.422

3.  Comparative analysis of mycobacterial infections in susceptible I/St and resistant A/Sn inbred mice.

Authors:  B V Nikonenko; M M Averbakh; C Lavebratt; E Schurr; A S Apt
Journal:  Tuber Lung Dis       Date:  2000

4.  Rapid, simple in vivo screen for new drugs active against Mycobacterium tuberculosis.

Authors:  Boris V Nikonenko; Rowena Samala; Leo Einck; Carol A Nacy
Journal:  Antimicrob Agents Chemother       Date:  2004-12       Impact factor: 5.191

5.  Distinct H-2 complex control of mortality, and immune responses to tuberculosis infection in virgin and BCG-vaccinated mice.

Authors:  A S Apt; V G Avdienko; B V Nikonenko; I B Kramnik; A M Moroz; E Skamene
Journal:  Clin Exp Immunol       Date:  1993-11       Impact factor: 4.330

6.  Influence of the mouse Bcg, Tbc-1 and xid genes on resistance and immune responses to tuberculosis infection and efficacy of bacille Calmette-Guérin (BCG) vaccination.

Authors:  B V Nikonenko; A S Apt; M B Mezhlumova; V G Avdienko; V V Yeremeev; A M Moroz
Journal:  Clin Exp Immunol       Date:  1996-04       Impact factor: 4.330

7.  Comparative analysis of T lymphocytes recovered from the lungs of mice genetically susceptible, resistant, and hyperresistant to Mycobacterium tuberculosis-triggered disease.

Authors:  I V Lyadova; E B Eruslanov; S V Khaidukov; V V Yeremeev; K B Majorov; A V Pichugin; B V Nikonenko; T K Kondratieva; A S Apt
Journal:  J Immunol       Date:  2000-11-15       Impact factor: 5.422

8.  The QTL within the H2 Complex Involved in the Control of Tuberculosis Infection in Mice Is the Classical Class II H2-Ab1 Gene.

Authors:  Nadezhda Logunova; Maria Korotetskaya; Vladimir Polshakov; Alexander Apt
Journal:  PLoS Genet       Date:  2015-11-30       Impact factor: 5.917

9.  Variable Virulence and Efficacy of BCG Vaccine Strains in Mice and Correlation With Genome Polymorphisms.

Authors:  Lu Zhang; Huan-Wei Ru; Fu-Zeng Chen; Chun-Yan Jin; Rui-Feng Sun; Xiao-Yong Fan; Ming Guo; Jun-Tao Mai; Wen-Xi Xu; Qing-Xia Lin; Jun Liu
Journal:  Mol Ther       Date:  2015-12-08       Impact factor: 11.454

10.  Tuberculosis Susceptibility and Vaccine Protection Are Independently Controlled by Host Genotype.

Authors:  Clare M Smith; Megan K Proulx; Andrew J Olive; Dominick Laddy; Bibhuti B Mishra; Caitlin Moss; Nuria Martinez Gutierrez; Michelle M Bellerose; Palmira Barreira-Silva; Jia Yao Phuah; Richard E Baker; Samuel M Behar; Hardy Kornfeld; Thomas G Evans; Gillian Beamer; Christopher M Sassetti
Journal:  mBio       Date:  2016-09-20       Impact factor: 7.867
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