| Literature DB >> 34542750 |
O V Iunikhina1, N V Krylova2, N P Mishchenko3, E A Vasileva3, S A Fedoreyev3, M Yu Shchelkanov2.
Abstract
The quinoid pigment echinochrome A isolated from the sea urchin Scaphechinus mirabilis, the product of its oxidation dehydroechinochrome, and structurally similar antiviral agent oxolin were tested for their ability to inhibit plaque formation induced by herpes simplex virus type 1 (HSV-1) in Vero cells. The tested compounds showed significant anti-HSV-1 activity, mainly due to their direct effect on viral particles and on virus attachment to cells. The antiviral efficacy of the test compounds increased in the following order: oxolin→echinochrome A→dehydroechinochrome.Entities:
Keywords: antiviral effect; dehydroechinochrome; echinochrome A; herpes simplex virus type 1
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Year: 2021 PMID： 34542750 DOI： 10.1007/s10517-021-05251-y
Source DB: PubMed Journal: Bull Exp Biol Med ISSN： 0007-4888 Impact factor: 0.804