Literature DB >> 34542746

Low-Molecular-Weight Mimetic of BDNF Loop 2 Reduces Ethanol Consumption in Female Rats.

L G Kolik1, A V Nadorova2, E M Grigorevskikh2, N M Sazonova2, T A Gudasheva2, A D Durnev2.   

Abstract

The study examined the effect of GTS-201, a low-molecular weight mimetic of brain-derived neurotrophic factor (BDNF) loop 2, on persistent alcohol craving in outbred male and female albino rats with ethanol preference score ~50% developed in the free choice paradigm between 10% ethanol and water over 24 weeks. Both single and subchronic (5 days) injections of GTS-201 in a daily dose of 5 μg/kg reduced alcohol deprivation effect in female, but not in male rats. The possibility of in vivo sex-dependent regulation of modeled alcohol craving with a low-molecular-weight dipeptide mimetic of BDNF loop 2 was demonstrated and sex-related differences in this effect were revealed.
© 2021. Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  BDNF mimetic; ethanol intake consumption; rats

Mesh：

Substances：

Year:  2021        PMID： 34542746     DOI： 10.1007/s10517-021-05245-w

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  13 in total

1.  Efficacy of peptide anxiolytic selank during modeling of withdrawal syndrome in rats with stable alcoholic motivation.

Authors:  L G Kolik; A V Nadorova; M M Kozlovskaya
Journal:  Bull Exp Biol Med       Date:  2014-06-10       Impact factor: 0.804

2.  Chronic ethanol administration decreases brain-derived neurotrophic factor gene expression in the rat hippocampus.

Authors:  A J MacLennan; N Lee; D W Walker
Journal:  Neurosci Lett       Date:  1995-09-08       Impact factor: 3.046

3.  Voluntary exercise decreases ethanol preference and consumption in C57BL/6 adolescent mice: sex differences and hippocampal BDNF expression.

Authors:  X Gallego; R J Cox; E Funk; R A Foster; M A Ehringer
Journal:  Physiol Behav       Date:  2014-10-24

4.  Alcohol preferring (P) rats as a model for examining sex differences in alcohol use disorder and its treatment.

Authors:  Catherine F Moore; Wendy J Lynch
Journal:  Pharmacol Biochem Behav       Date:  2015-02-21       Impact factor: 3.533

5.  Escalating ethanol intake is associated with altered corticostriatal BDNF expression.

Authors:  Marian L Logrip; Patricia H Janak; Dorit Ron
Journal:  J Neurochem       Date:  2009-03-28       Impact factor: 5.372

6.  Ethanol consumption and serotonin-1A (5-HT1A) receptor function in heterozygous BDNF (+/-) mice.

Authors:  J G Hensler; E E Ladenheim; W E Lyons
Journal:  J Neurochem       Date:  2003-06       Impact factor: 5.372

7.  Effects of short deprivation and re-exposure intervals on the ethanol drinking behavior of selectively bred high alcohol-consuming rats.

Authors:  Richard L Bell; Zachary A Rodd; Jonathon A Schultz; Caron L Peper; Lawrence Lumeng; James M Murphy; William J McBride
Journal:  Alcohol       Date:  2008-05-16       Impact factor: 2.405

8.  Dynorphin is a downstream effector of striatal BDNF regulation of ethanol intake.

Authors:  Marian L Logrip; Patricia H Janak; Dorit Ron
Journal:  FASEB J       Date:  2008-02-29       Impact factor: 5.191

9.  On the interaction between BDNF and serotonin systems: The effects of long-term ethanol consumption in mice.

Authors:  Nina K Popova; Tatiana V Ilchibaeva; Egor V Antonov; Arina V Pershina; Darya V Bazovkina; Vladimir S Naumenko
Journal:  Alcohol       Date:  2020-04-21       Impact factor: 2.405

10.  Activation of Melanocortin-4 Receptor Inhibits Both Neuroinflammation Induced by Early Exposure to Ethanol and Subsequent Voluntary Alcohol Intake in Adulthood in Animal Models: Is BDNF the Key Mediator?

Authors:  Osvaldo Flores-Bastías; Alfredo Adriasola-Carrasco; Eduardo Karahanian
Journal:  Front Cell Neurosci       Date:  2020-01-28       Impact factor: 5.505
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