Literature DB >> 34542743

Changes in Hemoglobin Isoforms in the Peripheral Blood of Rats with Experimental Posthemorrhagic Anemia.

B G Yushkov1,2,3, S A Brilliant4,5, A S Minin2.   

Abstract

Six hemoglobin isoforms were identified in the peripheral blood of male Wistar rats by PAAG electrophoresis. Erythrocytes can be separated into 6 fractions by fractional centrifugation; the fractions differ by the content of reticulocytes and cells with fetal hemoglobin. Cells in each fraction contain one light and one heavy hemoglobin isoforms, and their combination is specific to each fraction. Changes in the hemoglobin isoforms in the whole blood in case of blood loss can be associated with changes in physical and chemical properties of circulating erythrocytes, as well as with the formation of various cell populations resulting from activated erythropoiesis.
© 2021. Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  fetal hemoglobin; fractional centrifugation erythrocytes; hemoglobin heterogeneity; hemoglobin isoforms; hemorrhagic anemia

Mesh：

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Year:  2021        PMID： 34542743     DOI： 10.1007/s10517-021-05241-0

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  5 in total

1.  Hemoglobin heterogeneity under conditions of abnormal erythropoiesis.

Authors:  M N Sumin; A V Rezaikin; B G Yushkov
Journal:  Bull Exp Biol Med       Date:  2003-06       Impact factor: 0.804

2.  Gene duplication and the evolution of hemoglobin isoform differentiation in birds.

Authors:  Michael T Grispo; Chandrasekhar Natarajan; Joana Projecto-Garcia; Hideaki Moriyama; Roy E Weber; Jay F Storz
Journal:  J Biol Chem       Date:  2012-09-08       Impact factor: 5.157

Review 3.  Structure and function of haemoglobins.

Authors:  David A Gell
Journal:  Blood Cells Mol Dis       Date:  2017-10-31       Impact factor: 3.039

4.  Membrane interactions of hemoglobin variants, HbA, HbE, HbF and globin subunits of HbA: effects of aminophospholipids and cholesterol.

Authors:  Poppy Datta; Sudipa Chakrabarty; Amit Chakrabarty; Abhijit Chakrabarti
Journal:  Biochim Biophys Acta       Date:  2007-09-05

5.  Gene turnover in the avian globin gene families and evolutionary changes in hemoglobin isoform expression.

Authors:  Juan C Opazo; Federico G Hoffmann; Chandrasekhar Natarajan; Christopher C Witt; Michael Berenbrink; Jay F Storz
Journal:  Mol Biol Evol       Date:  2014-12-09       Impact factor: 16.240
  5 in total

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