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Literature DB >> 34537332

The past, present, and future of enzyme-based therapies.

Abstract

Enzyme-based therapeutics (EBTs) have the potential to tap into an almost unmeasurable amount of enzyme biodiversity and treat myriad conditions. Although EBTs were some of the first biologics used clinically, the rate of development of newer EBTs has lagged behind that of other biologics. Here, we review the history of EBTs, and discuss the state of each class of EBT, their potential clinical advantages, and the unique challenges to their development. Additionally, we discuss key remaining technical barriers that, if addressed, could increase the diversity and rate of the development of EBTs.

Entities: Chemical

Keywords: Biologic; Biotechnology; Clinical; Early investigational; Enzyme; Enzyme based therapy; History; Pre-clinical; Therapeutic enzymes; Therapy

Mesh：

Substances：
Enzymes

Year: 2021 PMID： 34537332 PMCID： PMC8714691 DOI： 10.1016/j.drudis.2021.09.004

Source DB: PubMed Journal: Drug Discov Today ISSN： 1359-6446 Impact factor: 7.851

144 in total

1. Biotechnological Applications of Marine Enzymes From Algae, Bacteria, Fungi, and Sponges.

Authors: S Parte; V L Sirisha; J S D'Souza
Journal: Adv Food Nutr Res Date: 2016-12-29

2. Thermosensitive Micelles Encapsulating Phenylalanine Ammonia Lyase Act as a Sustained and Efficacious Therapy Against Colorectal Cancer.

Authors: Jin Yang; Rui Tao; Li Wang; Linjiang Song; Yan Wang; Changyang Gong; Shaohua Yao; Qinjie Wu
Journal: J Biomed Nanotechnol Date: 2019-04-01 Impact factor: 4.099

3. Catalytic properties of human manganese superoxide dismutase.

Authors: J L Hsu; Y Hsieh; C Tu; D O'Connor; H S Nick; D N Silverman
Journal: J Biol Chem Date: 1996-07-26 Impact factor: 5.157

Review 4. Anti-PEG antibodies in the clinic: Current issues and beyond PEGylation.

Authors: Peng Zhang; Fang Sun; Sijun Liu; Shaoyi Jiang
Journal: J Control Release Date: 2016-06-28 Impact factor: 9.776

5. L-Asparaginase, vincristine, and prednisone for induction of first remission in acute lymphocytic leukemia.

Authors: J A Ortega; M E Nesbit; M H Donaldson; R E Hittle; J Weiner; M Karon; D Hammond
Journal: Cancer Res Date: 1977-02 Impact factor: 12.701

6. Protective effects of PEP-1-Catalase on stress-induced cellular toxicity and MPTP-induced Parkinson's disease.

Authors: Seon Ae Eom; Dae Won Kim; Min Jea Shin; Eun Hee Ahn; Seok Young Chung; Eun Jeong Sohn; Hyo Sang Jo; Su-Jeong Jeon; Duk-Soo Kim; Hyeok Yil Kwon; Sung-Woo Cho; Kyu Hyung Han; Jinseu Park; Won Sik Eum; Soo Young Choi
Journal: BMB Rep Date: 2015-07 Impact factor: 4.778

7. A Therapeutic Uricase with Reduced Immunogenicity Risk and Improved Development Properties.

Authors: Andrew C Nyborg; Chris Ward; Anna Zacco; Benoy Chacko; Luba Grinberg; James C Geoghegan; Ryan Bean; Michaela Wendeler; Frank Bartnik; Ellen O'Connor; Flaviu Gruia; Vidyashankara Iyer; Hui Feng; Varnika Roy; Mark Berge; Jeffrey N Miner; David M Wilson; Dongmei Zhou; Simone Nicholson; Clynn Wilker; Chi Y Wu; Susan Wilson; Lutz Jermutus; Herren Wu; David A Owen; Jane Osbourn; Steven Coats; Manuel Baca
Journal: PLoS One Date: 2016-12-21 Impact factor: 3.240

Review 8. ENHANZE^® drug delivery technology: a novel approach to subcutaneous administration using recombinant human hyaluronidase PH20

Authors: Kenneth W Locke; Daniel C Maneval; Michael J LaBarre
Journal: Drug Deliv Date: 2019-12 Impact factor: 6.419

The past, present, and future of enzyme-based therapies.

1. Biotechnological Applications of Marine Enzymes From Algae, Bacteria, Fungi, and Sponges.

2. Thermosensitive Micelles Encapsulating Phenylalanine Ammonia Lyase Act as a Sustained and Efficacious Therapy Against Colorectal Cancer.

3. Catalytic properties of human manganese superoxide dismutase.

Review 4. Anti-PEG antibodies in the clinic: Current issues and beyond PEGylation.

5. L-Asparaginase, vincristine, and prednisone for induction of first remission in acute lymphocytic leukemia.

6. Protective effects of PEP-1-Catalase on stress-induced cellular toxicity and MPTP-induced Parkinson's disease.

7. A Therapeutic Uricase with Reduced Immunogenicity Risk and Improved Development Properties.

Review 8. ENHANZE^® drug delivery technology: a novel approach to subcutaneous administration using recombinant human hyaluronidase PH20

9. Developing novel anthelmintics from plant cysteine proteinases.

10. A new recombinant MS-superoxide dismutase alleviates 5-fluorouracil-induced intestinal mucositis in mice.

1. Stabilizing proteins, simplified: A Rosetta-based webtool for predicting favorable mutations.

Review 4. Anti-PEG antibodies in the clinic: Current issues and beyond PEGylation.

Review 8. ENHANZE® drug delivery technology: a novel approach to subcutaneous administration using recombinant human hyaluronidase PH20

Review 8. ENHANZE^® drug delivery technology: a novel approach to subcutaneous administration using recombinant human hyaluronidase PH20