BACKGROUND: Adjuvant chemotherapy for 6 months following surgery is the standard treatment plan for stage III colon cancer. The aim of the present study was to determine whether the adjuvant chemotherapy completion time for stage III colon cancer had an effect on prognosis and cut-off time that affected the prognosis. METHODS: This was a retrospective study of stage III colon cancer patients who completed adjuvant chemotherapy at Guangzhou Red Cross Hospital from January 2010 to December 2017. Univariate and multivariate analyses were used to determine the association between adjuvant chemotherapy completion time and the 3-year disease-free survival (DFS). The restricted cubic spline model was used to analyze the cut-off time that affected the 3-year DFS. RESULTS: A total of 431 patients were included in the study. The 3-year DFS was associated with a combination of obstruction or perforation, preoperative serum carcino-embryonic antigen (CEA) concentration, T stage, N stage, pathological stage, and adjuvant chemotherapy completion time in the univariate analysis (P<0.05). A combination of obstruction or perforation, preoperative serum CEA concentration, N stage, and adjuvant chemotherapy completion time were independent prognostic factors in the multivariate analysis (P<0.05). The cut-off time was 28 weeks for adjuvant chemotherapy completion time in the restricted cubic spline model analysis. For those whose adjuvant chemotherapy completion time was >28 weeks, the risk of 3-year recurrence was 1.428 times higher compared with those whose adjuvant chemotherapy completion time was ≤28 weeks. [P=0.032, 95% confidence interval (CI): 1.034-2.055]. CONCLUSIONS: The 3-year DFS of stage III colon cancer was related to the adjuvant chemotherapy completion time. For those who completed adjuvant chemotherapy >28 weeks, the risk of 3-year recurrence increased. 2021 Journal of Gastrointestinal Oncology. All rights reserved.
BACKGROUND: Adjuvant chemotherapy for 6 months following surgery is the standard treatment plan for stage III colon cancer. The aim of the present study was to determine whether the adjuvant chemotherapy completion time for stage III colon cancer had an effect on prognosis and cut-off time that affected the prognosis. METHODS: This was a retrospective study of stage III colon cancer patients who completed adjuvant chemotherapy at Guangzhou Red Cross Hospital from January 2010 to December 2017. Univariate and multivariate analyses were used to determine the association between adjuvant chemotherapy completion time and the 3-year disease-free survival (DFS). The restricted cubic spline model was used to analyze the cut-off time that affected the 3-year DFS. RESULTS: A total of 431 patients were included in the study. The 3-year DFS was associated with a combination of obstruction or perforation, preoperative serum carcino-embryonic antigen (CEA) concentration, T stage, N stage, pathological stage, and adjuvant chemotherapy completion time in the univariate analysis (P<0.05). A combination of obstruction or perforation, preoperative serum CEA concentration, N stage, and adjuvant chemotherapy completion time were independent prognostic factors in the multivariate analysis (P<0.05). The cut-off time was 28 weeks for adjuvant chemotherapy completion time in the restricted cubic spline model analysis. For those whose adjuvant chemotherapy completion time was >28 weeks, the risk of 3-year recurrence was 1.428 times higher compared with those whose adjuvant chemotherapy completion time was ≤28 weeks. [P=0.032, 95% confidence interval (CI): 1.034-2.055]. CONCLUSIONS: The 3-year DFS of stage III colon cancer was related to the adjuvant chemotherapy completion time. For those who completed adjuvant chemotherapy >28 weeks, the risk of 3-year recurrence increased. 2021 Journal of Gastrointestinal Oncology. All rights reserved.
Authors: Víctor M Pérez-García; Gabriel F Calvo; Jesús J Bosque; Odelaisy León-Triana; Juan Jiménez; Julián Perez-Beteta; Juan Belmonte-Beitia; Manuel Valiente; Lucía Zhu; Pedro García-Gómez; Pilar Sánchez-Gómez; Esther Hernández-San Miguel; Rafael Hortigüela; Youness Azimzade; David Molina-García; Álvaro Martinez; Ángel Acosta Rojas; Ana Ortiz de Mendivil; Francois Vallette; Philippe Schucht; Michael Murek; María Pérez-Cano; David Albillo; Antonio F Honguero Martínez; Germán A Jiménez Londoño; Estanislao Arana; Ana M García Vicente Journal: Nat Phys Date: 2020-08-10 Impact factor: 20.034
Authors: Megan C Turner; Norma E Farrow; Kristen E Rhodin; Zhifei Sun; Mohamed A Adam; Christopher R Mantyh; John Migaly Journal: J Am Coll Surg Date: 2018-01-31 Impact factor: 6.113
Authors: Dawn Provenzale; Reid M Ness; Xavier Llor; Jennifer M Weiss; Benjamin Abbadessa; Gregory Cooper; Dayna S Early; Mark Friedman; Francis M Giardiello; Kathryn Glaser; Suryakanth Gurudu; Amy L Halverson; Rachel Issaka; Rishi Jain; Priyanka Kanth; Trilokesh Kidambi; Audrey J Lazenby; Lillias Maguire; Arnold J Markowitz; Folasade P May; Robert J Mayer; Shivan Mehta; Swati Patel; Shajan Peter; Peter P Stanich; Jonathan Terdiman; Jennifer Keller; Mary A Dwyer; Ndiya Ogba Journal: J Natl Compr Canc Netw Date: 2020-10-01 Impact factor: 11.908