Literature DB >> 34529476

Immune correlates of protection by mRNA-1273 vaccine against SARS-CoV-2 in nonhuman primates.

Kizzmekia S Corbett1, Martha C Nason2, Britta Flach1, Matthew Gagne1, Sarah O'Connell1, Timothy S Johnston1, Shruti N Shah1, Venkata Viswanadh Edara3, Katharine Floyd3, Lilin Lai3, Charlene McDanal4, Joseph R Francica1, Barbara Flynn1, Kai Wu5, Angela Choi5, Matthew Koch5, Olubukola M Abiona1, Anne P Werner1, Juan I Moliva1, Shayne F Andrew1, Mitzi M Donaldson1, Jonathan Fintzi1, Dillon R Flebbe1, Evan Lamb1, Amy T Noe1, Saule T Nurmukhambetova1, Samantha J Provost1, Anthony Cook6, Alan Dodson6, Andrew Faudree6, Jack Greenhouse6, Swagata Kar6, Laurent Pessaint6, Maciel Porto6, Katelyn Steingrebe6, Daniel Valentin6, Serge Zouantcha6, Kevin W Bock7, Mahnaz Minai7, Bianca M Nagata7, Renee van de Wetering1, Seyhan Boyoglu-Barnum1, Kwanyee Leung1, Wei Shi1, Eun Sung Yang1, Yi Zhang1, John-Paul M Todd1, Lingshu Wang1, Gabriela S Alvarado1, Hanne Andersen6, Kathryn E Foulds1, Darin K Edwards5, John R Mascola1, Ian N Moore7, Mark G Lewis6, Andrea Carfi5, David Montefiori4, Mehul S Suthar3,8, Adrian McDermott1, Mario Roederer1, Nancy J Sullivan1, Daniel C Douek1, Barney S Graham1, Robert A Seder1.   

Abstract

Immune correlates of protection can be used as surrogate endpoints for vaccine efficacy. Here, nonhuman primates (NHPs) received either no vaccine or doses ranging from 0.3 to 100 μg of the mRNA-1273 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine. mRNA-1273 vaccination elicited circulating and mucosal antibody responses in a dose-dependent manner. Viral replication was significantly reduced in bronchoalveolar lavages and nasal swabs after SARS-CoV-2 challenge in vaccinated animals and most strongly correlated with levels of anti–S antibody and neutralizing activity. Lower antibody levels were needed for reduction of viral replication in the lower airway than in the upper airway. Passive transfer of mRNA-1273–induced immunoglobulin G to naïve hamsters was sufficient to mediate protection. Thus, mRNA-1273 vaccine–induced humoral immune responses are a mechanistic correlate of protection against SARS-CoV-2 in NHPs.

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Year:  2021        PMID： 34529476      PMCID： PMC8449013          DOI： 10.1126/science.abj0299

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  44 in total

1.  Systemic and local immune responses to enhanced-potency inactivated poliovirus vaccine in premature and term infants.

Authors:  S C Adenyi-Jones; H Faden; M B Ferdon; M S Kwong; P L Ogra
Journal:  J Pediatr       Date:  1992-05       Impact factor: 4.406

2.  Nomenclature for immune correlates of protection after vaccination.

Authors:  Stanley A Plotkin; Peter B Gilbert
Journal:  Clin Infect Dis       Date:  2012-03-20       Impact factor: 9.079

3.  Immunoglobulin response in serum and secretions after immunization with live and inactivated poliovaccine and natural infection.

Authors:  P L Ogra; D T Karzon; F Righthand; M MacGillivray
Journal:  N Engl J Med       Date:  1968-10-24       Impact factor: 91.245

4.  Mucosal immunity induced by enhance-potency inactivated and oral polio vaccines.

Authors:  I M Onorato; J F Modlin; A M McBean; M L Thoms; G A Losonsky; R H Bernier
Journal:  J Infect Dis       Date:  1991-01       Impact factor: 5.226

5.  Mixture models for single-cell assays with applications to vaccine studies.

Authors:  Greg Finak; Andrew McDavid; Pratip Chattopadhyay; Maria Dominguez; Steve De Rosa; Mario Roederer; Raphael Gottardo
Journal:  Biostatistics       Date:  2013-07-24       Impact factor: 5.899

6.  Development of a Rapid Focus Reduction Neutralization Test Assay for Measuring SARS-CoV-2 Neutralizing Antibodies.

Authors:  Abigail Vanderheiden; Venkata Viswanadh Edara; Katharine Floyd; Robert C Kauffman; Grace Mantus; Evan Anderson; Nadine Rouphael; Sri Edupuganti; Pei-Yong Shi; Vineet D Menachery; Jens Wrammert; Mehul S Suthar
Journal:  Curr Protoc Immunol       Date:  2020-12

7.  Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates.

Authors:  Kizzmekia S Corbett; Barbara Flynn; Kathryn E Foulds; Joseph R Francica; Seyhan Boyoglu-Barnum; Anne P Werner; Britta Flach; Sarah O'Connell; Kevin W Bock; Mahnaz Minai; Bianca M Nagata; Hanne Andersen; David R Martinez; Amy T Noe; Naomi Douek; Mitzi M Donaldson; Nadesh N Nji; Gabriela S Alvarado; Darin K Edwards; Dillon R Flebbe; Evan Lamb; Nicole A Doria-Rose; Bob C Lin; Mark K Louder; Sijy O'Dell; Stephen D Schmidt; Emily Phung; Lauren A Chang; Christina Yap; John-Paul M Todd; Laurent Pessaint; Alex Van Ry; Shanai Browne; Jack Greenhouse; Tammy Putman-Taylor; Amanda Strasbaugh; Tracey-Ann Campbell; Anthony Cook; Alan Dodson; Katelyn Steingrebe; Wei Shi; Yi Zhang; Olubukola M Abiona; Lingshu Wang; Amarendra Pegu; Eun Sung Yang; Kwanyee Leung; Tongqing Zhou; I-Ting Teng; Alicia Widge; Ingelise Gordon; Laura Novik; Rebecca A Gillespie; Rebecca J Loomis; Juan I Moliva; Guillaume Stewart-Jones; Sunny Himansu; Wing-Pui Kong; Martha C Nason; Kaitlyn M Morabito; Tracy J Ruckwardt; Julie E Ledgerwood; Martin R Gaudinski; Peter D Kwong; John R Mascola; Andrea Carfi; Mark G Lewis; Ralph S Baric; Adrian McDermott; Ian N Moore; Nancy J Sullivan; Mario Roederer; Robert A Seder; Barney S Graham
Journal:  N Engl J Med       Date:  2020-07-28       Impact factor: 91.245

8.  SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients.

Authors:  Lirong Zou; Feng Ruan; Mingxing Huang; Lijun Liang; Huitao Huang; Zhongsi Hong; Jianxiang Yu; Min Kang; Yingchao Song; Jinyu Xia; Qianfang Guo; Tie Song; Jianfeng He; Hui-Ling Yen; Malik Peiris; Jie Wu
Journal:  N Engl J Med       Date:  2020-02-19       Impact factor: 91.245

9.  Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine.

Authors:  Fernando P Polack; Stephen J Thomas; Nicholas Kitchin; Judith Absalon; Alejandra Gurtman; Stephen Lockhart; John L Perez; Gonzalo Pérez Marc; Edson D Moreira; Cristiano Zerbini; Ruth Bailey; Kena A Swanson; Satrajit Roychoudhury; Kenneth Koury; Ping Li; Warren V Kalina; David Cooper; Robert W Frenck; Laura L Hammitt; Özlem Türeci; Haylene Nell; Axel Schaefer; Serhat Ünal; Dina B Tresnan; Susan Mather; Philip R Dormitzer; Uğur Şahin; Kathrin U Jansen; William C Gruber
Journal:  N Engl J Med       Date:  2020-12-10       Impact factor: 91.245

10.  Respiratory disease in rhesus macaques inoculated with SARS-CoV-2.

Authors:  Vincent J Munster; Friederike Feldmann; Brandi N Williamson; Neeltje van Doremalen; Lizzette Pérez-Pérez; Jonathan Schulz; Kimberly Meade-White; Atsushi Okumura; Julie Callison; Beniah Brumbaugh; Victoria A Avanzato; Rebecca Rosenke; Patrick W Hanley; Greg Saturday; Dana Scott; Elizabeth R Fischer; Emmie de Wit
Journal:  Nature       Date:  2020-05-12       Impact factor: 49.962
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  89 in total

1.  Higher Proinflammatory Cytokines Are Associated With Increased Antibody Titer After a Third Dose of SARS-CoV-2 Vaccine in Solid Organ Transplant Recipients.

Authors:  Andrew H Karaba; Xianming Zhu; Sarah E Benner; Olivia Akinde; Yolanda Eby; Kristy H Wang; Sharada Saraf; Jacqueline M Garonzik-Wang; Sabra L Klein; Justin R Bailey; Andrea L Cox; Joel N Blankson; Christine M Durand; Dorry L Segev; William A Werbel; Aaron A R Tobian
Journal:  Transplantation       Date:  2022-04-01       Impact factor: 4.939

2.  Immunogenicity and Reactogenicity of SARS-CoV-2 Vaccines in Patients With Cancer: The CANVAX Cohort Study.

Authors:  Vivek Naranbhai; Claire A Pernat; Alexander Gavralidis; Kerri J St Denis; Evan C Lam; Laura M Spring; Steven J Isakoff; Jocelyn R Farmer; Leyre Zubiri; Gabriela S Hobbs; Joan How; Andrew M Brunner; Amir T Fathi; Jennifer L Peterson; Mustafa Sakhi; Grace Hambelton; Elyssa N Denault; Lindsey J Mortensen; Lailoo A Perriello; Marissa N Bruno; Brittany Y Bertaux; Aleigha R Lawless; Monica A Jackson; Elizabeth Niehoff; Caroline Barabell; Christian N Nambu; Erika Nakajima; Trenton Reinicke; Cynthia Bowes; Cristhian J Berrios-Mairena; Onosereme Ofoman; Grace E Kirkpatrick; Julia C Thierauf; Kerry Reynolds; Henning Willers; Wilfredo-Garcia Beltran; Anand S Dighe; Rebecca Saff; Kimberly Blumenthal; Ryan J Sullivan; Yi-Bin Chen; Arthur Kim; Aditya Bardia; Alejandro B Balazs; A John Iafrate; Justin F Gainor
Journal:  J Clin Oncol       Date:  2021-11-09       Impact factor: 44.544

3.  An intranasally administrated SARS-CoV-2 beta variant subunit booster vaccine prevents beta variant replication in rhesus macaques.

Authors:  Yongjun Sui; Jianping Li; Hanne Andersen; Roushu Zhang; Sunaina K Prabhu; Tanya Hoang; David Venzon; Anthony Cook; Renita Brown; Elyse Teow; Jason Velasco; Laurent Pessaint; Ian N Moore; Laurel Lagenaur; Jim Talton; Matthew W Breed; Josh Kramer; Kevin W Bock; Mahnaz Minai; Bianca M Nagata; Hyoyoung Choo-Wosoba; Mark G Lewis; Lai-Xi Wang; Jay A Berzofsky
Journal:  PNAS Nexus       Date:  2022-06-17

4.  Humoral Immunogenicity of the mRNA-1273 Vaccine in the Phase 3 COVE Trial.

Authors:  Hana M El Sahly; Lindsey R Baden; Brandon Essink; David Montefiori; Adrian McDermont; Richard Rupp; Michael Lewis; Shobha Swaminathan; Carl Griffin; Veronica Fragoso; Vicki E Miller; Bethany Girard; Yamuna D Paila; Weiping Deng; Joanne E Tomassini; Robert Paris; Florian Schödel; Rituparna Das; Allison August; Brett Leav; Jacqueline M Miller; Honghong Zhou; Rolando Pajon
Journal:  J Infect Dis       Date:  2022-05-10       Impact factor: 7.759

Review 5.  Innate and Adaptive Immune Responses in the Upper Respiratory Tract and the Infectivity of SARS-CoV-2.

Authors:  Ranjan Ramasamy
Journal:  Viruses       Date:  2022-04-29       Impact factor: 5.818

6.  Evaluation of S1RBD-Specific IgG Antibody Responses following COVID-19 Vaccination in Healthcare Professionals in Cyprus: A Comparative Look between the Vaccines of Pfizer-BioNTech and AstraZeneca.

Authors:  Elie Deeba; George Krashias; Astero Constantinou; Dana Koptides; Anastasia Lambrianides; Christina Christodoulou
Journal:  Microorganisms       Date:  2022-05-04

Review 7.  Antibody-mediated neutralization of SARS-CoV-2.

Authors:  Henning Gruell; Kanika Vanshylla; Timm Weber; Christopher O Barnes; Christoph Kreer; Florian Klein
Journal:  Immunity       Date:  2022-05-13       Impact factor: 43.474

8.  Ethnoracial Disparities in SARS-CoV-2 Seroprevalence in a Large Cohort of Individuals in Central North Carolina from April to December 2020.

Authors:  Cesar A Lopez; Clark H Cunningham; Sierra Pugh; Katerina Brandt; Usaphea P Vanna; Matthew J Delacruz; Quique Guerra; D Ryan Bhowmik; Samuel J Goldstein; Yixuan J Hou; Margaret Gearhart; Christine Wiethorn; Candace Pope; Carolyn Amditis; Kathryn Pruitt; Cinthia Newberry-Dillon; John L Schmitz; Lakshmanane Premkumar; Adaora A Adimora; Ralph S Baric; Michael Emch; Ross M Boyce; Allison E Aiello; Bailey K Fosdick; Daniel B Larremore; Aravinda M de Silva; Jonathan J Juliano; Alena J Markmann
Journal:  mSphere       Date:  2022-05-19       Impact factor: 5.029

9.  Initial analysis of viral dynamics and circulating viral variants during the mRNA-1273 Phase 3 COVE trial.

Authors:  Rolando Pajon; Yamuna D Paila; Bethany Girard; Groves Dixon; Katherine Kacena; Lindsey R Baden; Hana M El Sahly; Brandon Essink; Kathleen M Mullane; Ian Frank; Douglas Denhan; Edward Kerwin; Xiaoping Zhao; Baoyu Ding; Weiping Deng; Joanne E Tomassini; Honghong Zhou; Brett Leav; Florian Schödel
Journal:  Nat Med       Date:  2022-02-10       Impact factor: 87.241

10.  Detailed analysis of antibody responses to SARS-CoV-2 vaccination and infection in macaques.

Authors:  Alexandra C Willcox; Kevin Sung; Meghan E Garrett; Jared G Galloway; Jesse H Erasmus; Jennifer K Logue; David W Hawman; Helen Y Chu; Kim J Hasenkrug; Deborah H Fuller; Frederick A Matsen Iv; Julie Overbaugh
Journal:  PLoS Pathog       Date:  2022-04-11       Impact factor: 7.464
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