Literature DB >> 34528645

Deuteration of terminal alkynes realizes simultaneous live cell Raman imaging of similar alkyne-tagged biomolecules.

Syusuke Egoshi1, Kosuke Dodo1,2, Kenji Ohgane1, Mikiko Sodeoka1,2.   

Abstract

Alkynes were employed as tags to observe small molecules in cells by Raman microscopy. Herein, simple deuteration was found to shift the vibrational frequency of the alkyne by 135 cm-1. Two-color Raman imaging of D-alkynes and H-alkynes made it possible to distinguish between and observe similar small molecules in live cells.

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Year:  2021        PMID: 34528645     DOI: 10.1039/d1ob01479j

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN: 1477-0520            Impact factor:   3.876


  2 in total

1.  Iridium-catalyzed α-selective deuteration of alcohols.

Authors:  Moeko Itoga; Masako Yamanishi; Taro Udagawa; Ayane Kobayashi; Keiko Maekawa; Yoshiji Takemoto; Hiroshi Naka
Journal:  Chem Sci       Date:  2022-07-06       Impact factor: 9.969

2.  Practical approaches to labelling terminal alkynes with deuterium.

Authors:  Melanie Y T Chan; Arbab Anwar; William J S Lockley
Journal:  J Labelled Comp Radiopharm       Date:  2022-02-02       Impact factor: 1.949

  2 in total

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