Literature DB >> 34525398

Real-Time SARS-CoV-2 Genotyping by High-Throughput Multiplex PCR Reveals the Epidemiology of the Variants of Concern in Qatar.

Mohammad R Hasan1, Mahesh K R Kalikiri2, Faheem Mirza3, Sathyavathi Sundararaju3, Anju Sharma3, Thabisile Xaba3, Stephan Lorenz2, Hiam Chemaitelly4, Reham A El-Kahlout5, Kin Ming Tsui6, Hadi M Yassine7, Peter V Coyle8, Abdullatif Al Khal5, Roberto Bertollini9, Mohamed H Al Thani9, Laith J Abu-Raddad4, Patrick Tang6.   

Abstract

Complementing whole genome sequencing strategies with high-throughput multiplex RT-qPCR genotyping allows for more comprehensive and real-time tracking of SARS-CoV-2 variants of concern. During the second and third waves of COVID-19 in Qatar, PCR genotyping, combined with Sanger sequencing of un-typeable samples, was employed to describe the epidemiology of the Alpha, Beta and Delta variants. A total of 9792 nasopharyngeal PCR-positive samples collected between April-June 2021 were successfully genotyped, revealing the importation and transmission dynamics of these three variants in Qatar.
Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Entities:  

Keywords:  COVID-19; Epidemiology; Genotyping; SARS-CoV-2; Variants of concern (VOC)

Mesh：

Year:  2021        PMID： 34525398     DOI： 10.1016/j.ijid.2021.09.006

Source DB:  PubMed          Journal:  Int J Infect Dis        ISSN： 1201-9712            Impact factor:   3.623


  16 in total

1.  Association of Prior SARS-CoV-2 Infection With Risk of Breakthrough Infection Following mRNA Vaccination in Qatar.

Authors:  Laith J Abu-Raddad; Hiam Chemaitelly; Houssein H Ayoub; Hadi M Yassine; Fatiha M Benslimane; Hebah A Al Khatib; Patrick Tang; Mohammad R Hasan; Peter Coyle; Zaina Al Kanaani; Einas Al Kuwari; Andrew Jeremijenko; Anvar Hassan Kaleeckal; Ali Nizar Latif; Riyazuddin Mohammad Shaik; Hanan F Abdul Rahim; Gheyath K Nasrallah; Mohamed Ghaith Al Kuwari; Adeel A Butt; Hamad Eid Al Romaihi; Mohamed H Al-Thani; Abdullatif Al Khal; Roberto Bertollini
Journal:  JAMA       Date:  2021-11-16       Impact factor: 56.272

2.  Severity of Illness in Persons Infected With the SARS-CoV-2 Delta Variant vs Beta Variant in Qatar.

Authors:  Adeel A Butt; Soha R Dargham; Hiam Chemaitelly; Abdullatif Al Khal; Patrick Tang; Mohammad R Hasan; Peter V Coyle; Anil G Thomas; Abdelsalam M Borham; Elli G Concepcion; Anvar H Kaleeckal; Ali Nizar Latif; Roberto Bertollini; Abdul-Badi Abou-Samra; Laith J Abu-Raddad
Journal:  JAMA Intern Med       Date:  2022-02-01       Impact factor: 21.873

3.  Comparative Analysis of Age, Sex, and Viral Load in Outpatients during the Four Waves of SARS-CoV-2 in A Mexican Medium-Sized City.

Authors:  Carlos Eduardo Covantes-Rosales; Victor Wagner Barajas-Carrillo; Daniel Alberto Girón-Pérez; Gladys Alejandra Toledo-Ibarra; Karina Janice Guadalupe Díaz-Reséndiz; Migdalia Sarahy Navidad-Murrieta; Guadalupe Herminia Ventura-Ramón; Mirtha Elena Pulido-Muñoz; Ulises Mercado-Salgado; Ansonny Jhovanny Ojeda-Durán; Aimée Argüero-Fonseca; Manuel Iván Girón-Pérez
Journal:  Int J Environ Res Public Health       Date:  2022-05-08       Impact factor: 4.614

4.  Application of human RNase P normalization for the realistic estimation of SARS-CoV-2 viral load in wastewater: A perspective from Qatar wastewater surveillance.

Authors:  Shimaa S El-Malah; Jayaprakash Saththasivam; Khadeeja Abdul Jabbar; Arun K K; Tricia A Gomez; Ayeda A Ahmed; Yasmin A Mohamoud; Joel A Malek; Laith J Abu Raddad; Hussein A Abu Halaweh; Roberto Bertollini; Jenny Lawler; Khaled A Mahmoud
Journal:  Environ Technol Innov       Date:  2022-06-22

5.  Evaluation of a commercial SARS-CoV-2 multiplex PCR genotyping assay for variant identification in resource-scarce settings.

Authors:  Chijioke N Umunnakwe; Zinhle N Makatini; Mathapelo Maphanga; Anele Mdunyelwa; Khamusi M Mlambo; Puseletso Manyaka; Monique Nijhuis; Annemarie Wensing; Hugo A Tempelman
Journal:  PLoS One       Date:  2022-06-24       Impact factor: 3.752

6.  COVID-19 disease severity in persons infected with the Omicron variant compared with the Delta variant in Qatar.

Authors:  Adeel A Butt; Soha R Dargham; Patrick Tang; Hiam Chemaitelly; Mohammad R Hasan; Peter V Coyle; Anvar H Kaleeckal; Ali Nizar Latif; Srusvin Loka; Riyazuddin M Shaik; Ahmed Zaqout; Muna A Almaslamani; Abdullatif Al Khal; Roberto Bertollini; Abdul-Badi Abou-Samra; Laith J Abu-Raddad
Journal:  J Glob Health       Date:  2022-07-06       Impact factor: 7.664

7.  A systematic review of Vaccine Breakthrough Infections by SARS-CoV-2 Delta Variant.

Authors:  Mengxin Zhang; Ying Liang; Dongsheng Yu; Bang Du; Weyland Cheng; Lifeng Li; Zhidan Yu; Shuying Luo; Yaodong Zhang; Huanmin Wang; Xianwei Zhang; Wancun Zhang
Journal:  Int J Biol Sci       Date:  2022-01-01       Impact factor: 6.580

8.  Introduction and expansion of the SARS-CoV-2 B.1.1.7 variant and reinfections in Qatar: A nationally representative cohort study.

Authors:  Laith J Abu-Raddad; Hiam Chemaitelly; Houssein H Ayoub; Peter Coyle; Joel A Malek; Ayeda A Ahmed; Yasmin A Mohamoud; Shameem Younuskunju; Patrick Tang; Zaina Al Kanaani; Einas Al Kuwari; Adeel A Butt; Andrew Jeremijenko; Anvar Hassan Kaleeckal; Ali Nizar Latif; Riyazuddin Mohammad Shaik; Hanan F Abdul Rahim; Gheyath K Nasrallah; Hadi M Yassine; Mohamed Ghaith Al Kuwari; Hamad Eid Al Romaihi; Mohamed H Al-Thani; Abdullatif Al Khal; Roberto Bertollini
Journal:  PLoS Med       Date:  2021-12-16       Impact factor: 11.069

9.  Relative infectiousness of SARS-CoV-2 vaccine breakthrough infections, reinfections, and primary infections.

Authors:  Laith J Abu-Raddad; Hiam Chemaitelly; Houssein H Ayoub; Patrick Tang; Peter Coyle; Mohammad R Hasan; Hadi M Yassine; Fatiha M Benslimane; Hebah A Al-Khatib; Zaina Al-Kanaani; Einas Al-Kuwari; Andrew Jeremijenko; Anvar Hassan Kaleeckal; Ali Nizar Latif; Riyazuddin Mohammad Shaik; Hanan F Abdul-Rahim; Gheyath K Nasrallah; Mohamed Ghaith Al-Kuwari; Adeel A Butt; Hamad Eid Al-Romaihi; Abdullatif Al-Khal; Mohametabd H Al-Thani; Roberto Bertollini
Journal:  Nat Commun       Date:  2022-01-27       Impact factor: 14.919

10.  Estimates of global SARS-CoV-2 infection exposure, infection morbidity, and infection mortality rates in 2020.

Authors:  Houssein H Ayoub; Ghina R Mumtaz; Shaheen Seedat; Monia Makhoul; Hiam Chemaitelly; Laith J Abu-Raddad
Journal:  Glob Epidemiol       Date:  2021-11-23
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