Associations Between Kidney Dysfunction and Risk Factors in Patients with Transurethral Resection of the Prostate.

PURPOSE: Benign prostate hyperplasia (BPH) with urinary retention can result in kidney dysfunction. Several risk factors might influence deterioration in kidney function. The aims of this study were to assess the association between kidney dysfunction and risk factors in patients with transurethral resection of the prostate (TURP).
METHODS: We reviewed medical records of BPH patients managed by TURP and having high levels of blood urea and creatinine. Data collected were age, history of hypertension, diabetes mellitus (DM), urinary tract infection (UTI), urinary retention, and urinary tract stones, duration of obstruction, and blood-urea and -creatinine levels before and after TURP. Chi-suare and paired t- tests were used.
RESULTS: There were 64 patients in the study. More were aged 60-69 years (42.2%) than other age-groups, 53.1% had a history of hypertension, 12.5% DM, 35.9% UTI, all urinary retention, 14.1% urinary tract stones, and 92.2% obstruction duration <14 days. There were significant differences in blood-urea and -creatinine levels between before and after TURP (p<0.001). There were no significant differences between age-group, hypertension, DM, UTI, urinary retention, urinary stones, or duration of obstruction with kidney dysfunction after TURP (p>0.001).
CONCLUSION: Age, hypertension, DM, UTI, urinary retention, urinary tract stones, and duration of obstruction can be risk factors of kidney dysfunction in TURP patients, and TURP might improve blood-urea and -creatinine levels. There was no significant association between kidney recovery and kidney dysfunction with the number of risk factors in TURP and pre-TURP patients.

Introduction

Benign prostate hyperplasia (BPH) is the second–most common disease in urology clinics in Indonesia. In Pekanbaru, BPH is the most common pathology in urology clinics. We found 456 BPH cases in 2011–2014 in Arifin Achmad Hospital, Riau Province.1

The prevalence of BPH histopathology in autopsy studies increased from around 20% in men aged 41–50 years to 50% in men aged 51–60 years and >90% in men over 80 years old. In 55-year-olds, about 25% experience obstructive symptoms when urinating. In 75-year-olds, 50% complain of a decrease in the strength and caliber of urinary flow.2

Risk factors of BPH are age 40 years or older, family history of BPH, obesity, heart disease, circulatory disorders, type 2 diabetes mellitus (DM), lack of exercise, and erectile dysfunction.3 In addition, BPH patients with erectile dysfunction also exhibit comorbiditiies.6 Comorbidity of metabolic syndrome has a strong association with increased incidence of BPH/lower urinary tract symptoms (LUTSs), especially in patients with DM, hypertension, and obesity.4

Transurethral resection of the prostate (TURP) has been the gold standard for endoscopic surgical therapy for BPH for >30 years.5 TURP is an operation to remove enlarged parts of the prostate gland, causing the urethra to become depressed. This is the most common type of surgery to treat prostate enlargement.6 In Arifin Achmad Hospital in 2009–2010, there were 122 cases of BPH that had undergone TURP.7 Although TURP is the main choice in BPH therapy, the possibility of complications is unavoidable.1

Impaired kidney function might occur because of complications due to BPH. Disorders of kidney function include acute kidney injury (AKI), chronic kidney disease (CKD), and AKI with CKD.8 AKI is a condition in which the glomerular filtration rate is abruptly reduced, causing a sudden retention of endogenous and exogenous metabolites (eg, urea, potassium, phosphate, and sulfate) that are normally cleared by the kidneys. Causes of AKI are prerenal, functional hemodynamic, vascular, parenchymal intrarenal, and postrenal one. BPH has a postrenal cause.8 If BPH is not managed properly, it can lead to complications in the form of acute urinary retention, chronic kidney failure, recurrent urinary tract infections, bladder decompensation,9 hematuria, and kidney insufficiency.10 Potential causes of CKD include DM, hypertension, autoimmune diseases, systemic infections, urinary tract infections, urinary tract stones, LUT obstruction, neoplasma, family history of CKD, recovery from previous AKI, kidney-mass reduction, exposure to certain drugs (antihypertensive), and low birth weight.11

Methods

This was a retrospective descriptive study. We reviewed the medical records of patients with kidney-function impairment who had underwentgone TURP in the Urology Department of Arifin Achmad Hospital from January 2013 to December 2017. Data collected were age, history of hypertension, DM, urinary tract infection, urinary retention, urinary tract stones, duration of obstruction, and blood-urea and -creatinine levels on laboratory results before and after TURP. BPH with urinary retention is an indication for TURP, which is the gold standard of management. Statistical analysis used were Chi-square and paired t-tests. Study approval was obtained from the Ethical Review Board for Medicine and Health Research, Medical Faculty, Riau University.

Results

There were 64 patients in this study. The largest age-group was 60- to 69-year-olds (27, 42.2%) and the smallest 40- to 49-year-olds (one, 1.6%). There were 34 (53.1%) patients with a history of hypertension and 30 (46.9%) who did not. There were eight (12.5%) patients with a history of DM and 56 (87.5%) who did not. There were 23 (35.9%) patients with a history of urinary tract infections and 41 (64.1%) who did not, whereas all study patients had a history of urinary retention. There were nine (14.1%) patients with a history of urinary tract stones and 55 (85.9%) who did not. A majority of patients had had obstruction <14 days in (59, 92.2%) and five (7.8%) >14 days. (Table 1).

Table 1

Risk factors

Age-group (years)	n	%
40–49	1	1.6
50–59	10	15.6
60–69	27	42.2
70–79	19	29.7
>80	7	10.9
Total	64	100
History of hypertension
Yes	34	53.1
No	30	46.9
Total	64	100
History of DM
Present	8	12.5
Absent	56	87.5
Total	64	100
History of UTI
Present	23	35.9
Absent	41	64.1
Total	64	100
History of urinary retention
Present	64	100
Absent	0
Total	64	100
History of urinary tract stones
Present	9	14.1
Absent	55	85.9
Total	64	100
Duration of obstruction (days)
<14	59	92.2
≥14	5	7.8
Total	64	100

Analysis with paired t-tests (Table 2) was carried out to determine differences between blood-urea and -creatinine levels before and after TURP. Blood-urea levels showed a mean of 47.17 before TURP and 35.67 after TURP, and creatinine levels 1.82 before TURP and 1.10 after TURP. Urea levels showed t=6.26 and creatinine levels t=10.12. There were significant differences (p=0.001) between urea and creatinine levels before and after TURP.

Table 2

Blood-urea and -creatinine levels before and after TURP

	n	Mean	t	p
Blood urea
Before TURP	64	47.17	6.26	0.001
After TURP	64	35.67
Blood creatinine
Before TURP	64	1.82	10.12	0.001
After TURP	64	1.10

There were no significant associations of age-group (p=0.277), history of hypertension (p=0.97), history of DM (p=0.183), history of UTI (p=0.356), history of urinary retention (NA), history of urinary stones (p=0.670), or duration of obstruction (p=0.277) with recovery of urea levels after TURP (Table 3).

Table 3

Relationship between risk factors and renal recovery based on urea levels after TURP

	Renal recovery (urea)		p
	Normal	High
Age-group (years)
<40	4(57.1%)	3(42.9%)	0.277
40–49	1(100%)	0
50–59	10(100%)	0
60–69	21(77.8%)	6(22.2%)
70–79	14(73.7%)	5(26.3%)
History of hypertension
Yes	26(76.5%)	8(23.5%)	0.97
No	24(80%)	0(20%)
History of DM
Yes	8(100%)	0	0.183
No	42(75%)	14(25%)
History of UTI
Yes	16(69.9%)	7(30.4%)	0.356
No	34(82.9%)	7(7.17%)
History of urinary retention
Yes	50(78.1%)	14(21.9)	NA
No	—	—
History of urinary stones
Yes	8(88.9%)	1(11%)	0.670
No	42(76.4%)	13(23.6%)
Duration of obstruction (days)
<14	45(76.3%)	14(23.7%)	0.277
≥14	5(100%)	0

Note: p < 0.001.

Abbreviation: NA, not analyzed.

Table 4 shows that there were no significant associations of age-group (p=0.277), history of hypertension (p=0.97), history of DM (p=0.183), history of UTI (p=0.356), history of urinary retention (NA), history of urinary tract stones (p=0.670), or duration of obstruction (p=0.277) with recovery of creatinine levels after TURP.

Table 4

Relationship between risk factors and renal recovery based on creatinine levels after TURP

	Renal recovery (creatinine)		p
	Normal	High
Age-group (years)
<40	6(85.7%)	0	0.947
40–49	1(100%)	0
50–59	9(90%)	1(10%)
60–69	25(92.6%)	2(7.4%)
70–79	18(94.7%)	1(5.3%)
History of hypertension
Yes	31(91.2%)	3(8.8%)	1
No	28(93.3%)	2(6.7%)
History of DM
Yes	8(100%)	0	0.860
No	1(12.5%)	8(100%)
History of UTI
Yes	19(82.6%)	4(17.4%)	0.052
No	40(97.6%)	1(2.4%)
History of urinary retention
Yes	59(92.2%)	5(7.8%)	NA
No	—	—
History of urinary stones
Yes	8(88.9%)	1(11%)	0.544
No	51(92.7%)	4(7.3%)
Duration of obstruction (days)
<14	54(91.5%)	5(8.5%)	1
≥14	5(100%)	0

Note: p < 0.005.

Abbreviation: NA, not analyzed.

Table 5 shows that there were no significant associations of age-group (p=0.277), history of hypertension (p=0.230), history of DM (p=0.128), history of UTI (p=0.768), history of urinary retention (NA), history of urinary tract stones (p=0.670), or duration of obstruction (p=0.218) with kidney dysfunction (urea levels) before TURP. Table 5 also shows that the chances of influencing kidney-dysfunction occurrence before TURP were 0.4 based on history of hypertension (OR 0.477), 0.1 based on history of DM (OR 0.153), 0.3 based on history of UTI (p=0.768) and urinary retention (NA), 0.6 times based on urinary tract stones (OR 0.6) and 0.1 based on duration of obstruction (OR 0.17) that of kidney-dysfunction (urea levels) before TURP.

Table 5

Association between risk factors and renal dysfunction based on urea levels

	Renal dysfunction (urea)		OR	p
	Normal	High
Age-group (years)
<40	0	7(100%)	NA	0.846
40–49	0	1(100%)
50–59	7(70%)	3(30%)
60–69	15(55.6%)	12(44.4%)
70–79	6(31.6%)	13(68.4%)
History of hypertension
Yes	1(12.5%)	7(87%)	0.477	0.230
No	27(48.2%)	29(100%)
History of DM
Yes	1(12.5%)	8(100%)	0.153	0.128
No	1(12.5%)	8(100%)
History of UTI
Yes	6(26.1%)	17(73.9%)	0.305	0.768
No	22(53.7%)	19(46.3%)
History of urinary retention
Yes	1(1.6%)	63(98.4%)	NA	NA
No	6(31.6%)	13(68.4%)
History of urinary stones
Yes	28(43.8%)	36(56.2%)	0.600	0.720
No	25(45.5%)	30(54.5%)
Duration of obstruction (days)
<14	24(40.7%)	35(59.3%)	0.171	0.218
≥14	4(80%)	1(20%)

Note: p < 0.001.

Abbreviation: NA, not analyzed.

Table 6 shows that there were no significant associations of age-group (p=0.846), history of hypertension (p=1), history of DM (p=0.128), history of UTI (p=0.768), history of urinary retention (NA), history of urinary tract stones (p=1), or duration of obstruction (p=0.218) with kidney dysfunction (creatinine levels) before TURP. Table 5 The chances of influencing kidney-dysfunction occurrence before TURP were not analyzed.

Table 6

Association between risk factors and renal dysfunction based on creatinine levels

	Renal dysfunction (creatinine)		OR	p
	Normal	High
Age-group (years)
<40	0	1(2.8%)	NA	0.846
40–49	0	10(15.9%)
50–59	1(100%)	26(41.3%)
60–69	0	19(30.2%)
70–79	0	7(11.1%)
History of hypertension
Yes	1(2.9%)	33(97.1%)	NA	1
No	0	30(100%)
History of DM
Yes	0(12.5%)	8(100%)	NA	0.128
No	22(53.7%)	29(51.8%)
History of UTI
Yes	1(4.3%)	22(95.7%)	NA	0.768
No	0	41(100%)
History of urinary retention
Yes	1(1.6%)	63(98.4%)	NA	0.020
No	6(31.6%)	13(68.4%)
History of urinary stones
Yes	0	9(100%)	NA
No	25(45.5%)	30(54.5%)
Duration of obstruction (days)
<14	24(40.7%)	35(59.3%)	NA
≥14	4(80%)	1(20%)

Note: p < 0.001.

Abbreviation: NA, not analyzed.

Discussion

Those aged 60–69 years were most likely to have impaired kidney function (27 patients, 42.2%). There was an association between BPH and increased age: decreased male hormone levels, especially testosterone,11,12 leading to a significant reduction in kidney function.13 Hidayati found BPH in TURP patients was mostly in 60- 69-year-old group (21 patients, 50%).14 The 2006 National Health and Nutrition Examination Survey found that the most predominant age-group exhibiting CKD was those aged 60 years and over (39.4%), followed by 40–59 years (12.6%) and 20–39 years(8.5%).15

High blood pressure might result in kidney function declining until kidney failure.16 In this study, there were 34 (53.1%) patients with a history of hypertension, in line with a study that showed risk factors of chronic kidney-function disorders: of 100 subjects, 45 (45%) had hypertension.17 Adhiatama et al found that 23 (63.9%) patients had a history of hypertension in chronic kidney failure.18 Hervinda found that 126 (68.9%) patients had a history of hypertension with CKD.19

In this study there were eight (12.5%) patients who had a history of DM. This is in line with the Adhiatama et al, who found eight (1.9%) patients with CKD with a history of DM,19 and also in line with Hervinda, who found 33.3% of CKD patients with a history of high DM.20 DM results in decreased kidney-filtering function, resulting in the body gaining a lot of waste. If this continues, it will cause chronic kidney failure.19

This study showed UTI history in 23 (35.9%) patients. UTI is one of the risk factors of CKD. The occurrence of UTI accompanied by vesicoureteral reflux can increase scar formation in the kidneys, which results in a decrease in kidney function.17,21 This result is in line with Hsiao, who showed that 46.4% of patients with AKI had a history of upper UTI,22 anda study of 100 patients diagnosed with acute pyelonephritis (upper UTI), where 47 (47%) patients had AKI.23 However, our result was not in line with Rollino et al, who found that of 223 patients with pyelonephritis, only 21 (9.4%) had AKI.24 Our result was also different from Hervinda, who found 26 (14.2%) patients of 183 with a history of UTI.20

We found that all patients had a history of urinary retention. Men aged 50–60 years are prone to urinary retention in BPH. In some people, urinary retention can cause kidney damage because of the backflow of urine to the kidneys, which can cause scarring of the kidneys.25 Our result was in line with Vaidyanathan for the increase in temperature.;26 Speakman found chronic urinary retention was a major cause of CKD in patients with LUTSs/BPH. Imaging tests should be done to assess hydronephrosis and measure serum eGFR and creatinine. It is possible to treat renal dysfunction with TURP so it can improve post-TURP kidney function.27

There were nine (14.1%) people with urinary stone history. Obstruction caused by urinary tract stones can cause an increase in intratubular pressure, followed by vasoconstriction of blood vessels causing ischemia in the kidneys. Long-term ischemia can cause glomerulosclerosis, tubular atrophy, and interstitial fibrosis.28 Our results are in line with Hervinda et al, who found that in 182 CKD patients, 21 (11.5%) had a history of urinary tract stones,20 and Kartha et al, who found 0.8%–17.5% of CKD patients with urinary tract stone disease.29

We found that patients with renal dysfunction had a duration of obstruction <14 days, or acute obstruction in 59 (92.2%) patients, and those with >14 days or chronic obstruction numbered five (7.8%). Obstructive uropathy is anatomical and functional obstruction in all levels of the urinary tract: from the kidney, ureter, and bladder to the urethra.30 If the obstruction persists or is chronic, the pelvic and calyx of the kidney dilate, representing hydronephrosis.31 Damage to nephrons that undergo hydronephrosis depends on blockage degree, duration of obstruction, renal pelvic anatomy, degree of disruption of blood vessels, and presence or absence of concomitant infections.32

Blood-urea levels can identify a decrease in kidney function.33 A decline in kidney function might be also identified based on blood-creatinine levels.34 We found that there was a significant difference between blood-urea and -creatinine levels (p=0.001) before and after TURP. This result is in line with Zamzami, who examined urinary and creatinine levels in obstructive uropathy patients who experienced BPH after undergoing TURP. In that study also, there was a significant difference between urea levels before and after TURP (p<0.001).35

Our research also supports the results of Riyach et al in men aged ≥65 years who had prostate enlargement and impaired kidney function with blood-urea levels of 43.5 mg/dL. After surgery and being observed for 3 months, patients were able to urinate well and showed no decrease in kidney function.36 The results of this study have similarities with Thasinas et al, who found that there was a change in blood-urea levels after surgery.37 Zamzami also found a significant difference in creatinine levels before and after TURP.37 Our results were also in line with Amar, who found patient creatinine levels on the second day after surgery were 1.6±0.2 mg/dL and 1.56 mg/dL on day 14, and remained constant until 6 weeks after surgery.38,39

There were no significant associations between age-group, history of hypertension, history of DM, history of UTI, history of urinary retention, history of urinary tract stones, or duration of obstruction with recovery of urea levels after TURP. Also, there were no significant associations between age-group, history of hypertension, history of DM, history of UTI, history of urinary retention, history of urinary tract stones, or duration of obstruction with recovery of creatinine levels after TURP. We concluded that there was no significant association between kidney recovery and risk factors in TURP patients.

There were no significant differences between age-group, history of hypertension, history of DM, history of UTI, history of urinary retention, history of urinary tract stones, or duration of obstruction with kidney dysfunction (urea levels) before TURP. The chances of influencing kidney-dysfunction occurrence before TURP were 0.4 times for history of hypertension, 0.1 times for history of DM, 0.3 times for history of UTI, history of urinary retention, 0.6 times for history of urinary tract stones, and 0.1 times for duration of obstruction with kidney dysfunction (urea levels) before TURP.

There were no significant differences between age-group, history of hypertension, history of DM, history of UTI, history of urinary retention, history of urinary tract stones, or duration of obstruction with kidney dysfunction (creatinine levels) before TURP. It was concluded that there was no significant association between renal dysfunction and number of risk factors in pre-TURP patients and little chance of an influence on kidney dysfunction (urea levels) occurrence in patients with TURP. Sarier et al showed that TURP can be safely and successfully applied for the treatment of BPH after renal transplant, and also that LUTSs and renal function significantly improve after the operation.40 Volpe et al showed that TURP for LUT obstruction attributable to BPH in renal transplantation is safe and effective, since it improves urinary flow, bladder emptying, and related urinary symptoms. TURP affords an early significant improvement in graft function that is maintained at 48 months.41

Conclusion

Age, history of hypertension, DM, urinary tract infections, urinary retention, urinary tract stones, and duration of obstruction can be risk factors of kidney dysfunction in TURP patients, and TURP might improve blood-urea and -creatinine levels. There were no significant associations between kidney recovery and kidney dysfunction with number of risk factors in TURP and pre-TURP patients and little chance of influencing kidney dysfunction (urea levels) occurrence in patients before TURP.