Ping Liu1, Shuying Zhang2, Lijuan Jiang3, Jinhong Ma2, Xiaonan Shao4. 1. Department of Geriatrics, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China. 2. Department of Clinical Laboratory, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China. 3. Department of Clinical Laboratory, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China. czyyjlj@126.com. 4. Department of Nuclear Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China.
Abstract
BACKGROUND: To explore the relationship between low-density lipoprotein cholesterol (LDL-C) level and infection risk in elderly stage 5 kidney disease (CKD) patients. METHODS: This study retrospectively analyzed all 378 patients with grade 5 CKD over 60 years old treated in the Nephrology Department of our hospital from February 2014 to July 2019, including 286 cases with infection and 92 cases without. According to LDL-C levels, the patients were divided into three groups (Tertile 1-Tertile 3). Basic patient data and laboratory test results were collected for all three groups for analysis. RESULTS: The incidence of infection showed a gradually decreasing trend in the three groups (from 80.2, 78.6 to 68.3%), along with increasing LDL-C levels from Tertile 1 to Tertile 3, although the differences were not statistically significant (p = 0.075). After fully adjusting for confounding factors, the risk of infection was significantly reduced (OR = 0.646, 95% CI 0.420-0.993, p = 0.046) with increasing LDL-C levels. For the LDL-C levels of the three groups, the rising trend of LDL-C was significantly associated with the reduction in infection risk (OR = 0.545, 95% CI 0.317-0.937, p = 0.028). Curve fitting revealed that LDL-C levels were linearly negatively associated with the risk of infection, and the relationship between the two was not affected by the other factors (p for interaction: 0.567-1.000). CONCLUSIONS: LDL-C level is linearly negatively associated with the risk of infection in elderly patients with stage 5 CKD.
BACKGROUND: To explore the relationship between low-density lipoprotein cholesterol (LDL-C) level and infection risk in elderly stage 5 kidney disease (CKD) patients. METHODS: This study retrospectively analyzed all 378 patients with grade 5 CKD over 60 years old treated in the Nephrology Department of our hospital from February 2014 to July 2019, including 286 cases with infection and 92 cases without. According to LDL-C levels, the patients were divided into three groups (Tertile 1-Tertile 3). Basic patient data and laboratory test results were collected for all three groups for analysis. RESULTS: The incidence of infection showed a gradually decreasing trend in the three groups (from 80.2, 78.6 to 68.3%), along with increasing LDL-C levels from Tertile 1 to Tertile 3, although the differences were not statistically significant (p = 0.075). After fully adjusting for confounding factors, the risk of infection was significantly reduced (OR = 0.646, 95% CI 0.420-0.993, p = 0.046) with increasing LDL-C levels. For the LDL-C levels of the three groups, the rising trend of LDL-C was significantly associated with the reduction in infection risk (OR = 0.545, 95% CI 0.317-0.937, p = 0.028). Curve fitting revealed that LDL-C levels were linearly negatively associated with the risk of infection, and the relationship between the two was not affected by the other factors (p for interaction: 0.567-1.000). CONCLUSIONS: LDL-C level is linearly negatively associated with the risk of infection in elderly patients with stage 5 CKD.
Authors: Marie Cooke; Claire Rickard; Ivan Rapchuk; Kiran Shekar; Andrea P Marshall; Tracy Comans; Suhail Doi; John McDonald; Amy Spooner Journal: BMJ Open Date: 2014-11-13 Impact factor: 2.692
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