Ali Zeraatkar Moghaddam1, Amir Ehsan Bameri1, Mohammad Reza Ganjali2,3, Michal Alexovič4, Mehdi Erfani Jazi5, Hadi Tabani6. 1. Department of Chemistry, Faculty of Science, University of Birjand, Birjand, South Khorasan, Iran. 2. Center of Excellence in Electrochemistry, School of Chemistry, College of Science, University of Tehran, Tehran, Iran. 3. Biosensor Research Center, Endocrinology & Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. 4. Department of Medical & Clinical Biophysics, Faculty of Medicine, University of P.J. Šafárik in Košice, SK-04011, Košice, Slovakia. 5. Department of Chemistry, Mississippi State University, Mississippi State, Mississippi, MS 39762, USA. 6. Department of Environmental Geology, Research Institute of Applied Sciences (ACECR), Shahid Beheshti University, Tehran, Iran.
Abstract
Aim: Hollow-fiber-based supported liquid membrane was modified utilizing nanostructures such as graphite, graphene oxide or nitrogen-doped graphene oxide, for electro-membrane extraction (EME) of imatinib and sunitinib from biological fluids. By applying these conductive nanostructures, a low-voltage EME device (6.0 V) was fabricated. Materials & methods: A response surface methodology through central composite design was used to evaluate and optimize effects of various essential factors that influence on normalized recovery. Results: Optimal extraction conditions were set as, 1-octanol with 0.01 % (w/v) graphene oxide functioning as the supported liquid membrane, an extraction time of 17.0 min, pH of the acceptor and the donor phase of 2.8 and 7.9, respectively. Conclusion: The method was successfully applied to quantify imatinib and sunitinib in biological fluids.
Aim: Hollow-fiber-based supported liquid membrane was modified utilizing nanostructures such as graphite, graphene oxide or nitrogen-doped graphene oxide, for electro-membrane extraction (EME) of imatinib and sunitinib from biological fluids. By applying these conductive nanostructures, a low-voltage EME device (6.0 V) was fabricated. Materials & methods: A response surface methodology through central composite design was used to evaluate and optimize effects of various essential factors that influence on normalized recovery. Results: Optimal extraction conditions were set as, 1-octanol with 0.01 % (w/v) graphene oxide functioning as the supported liquid membrane, an extraction time of 17.0 min, pH of the acceptor and the donor phase of 2.8 and 7.9, respectively. Conclusion: The method was successfully applied to quantify imatinib and sunitinib in biological fluids.